Targetable modifiers of T cell exclusion in KrasG12D-driven colorectal cancer liver metastases (P02)

• Subject Area: Hematology, Oncology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 441891347

In the project we examine how oncogenic KRAS mutations influence hepatic stellate cells (HSCs) and metastasis-associated fibroblasts (MAFs) in colorectal liver metastases (CRLM). We will be using ex vivo co-culture systems with tumor organoids carrying different oncogenic mutations and validate our findings in established in vivo models. Additionally, we aim to explore how KRAS-G12D influences hepatic stellate cell conditioning in the premetastatic niche, to assess whether modifying MAF polarization, HSC conditioning, and oncogenic signaling could enhance immunotherapy for colorectal liver metastases.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1479: Oncogene-driven immune escape (OncoEscape)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Florian R. Greten