SFB 1479:  Oncogene-driven immune escape (OncoEscape)

• Subject Area: Medicine ; Biology
• Term: since 2021
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 441891347

No abstract available

• DFG Programme: Collaborative Research Centres
• International Connection: Switzerland

Current projects

• P01 - Targeting MDM2-induced p53 downregulation to enhance anti-leukaemia immunity (Project Head Zeiser, Robert )
• P02 - Targetable modifiers of T cell exclusion in KrasG12D -driven colorectal cancer (Project Head Greten, Florian R. )
• P03 - The role of oncogene-driven activation of the CMTM6 / PD-L1 axis in leukaemia immune escape (Project Head Köhler, Natalie )
• P04 - The role of the NPM-ALK / PD-1 axis for immune response to T cell lymphoma (Project Head Illert, Lena )
• P05 - Oncogene-driven adenosine production by leukaemic stem cells promotes their immune escape (Project Heads Cabezas-Wallscheid, Nina ;  Kierdorf, Katrin )
• P06 - Oncogene-driven inflammasome activity in myeloid neoplasms and its impact on leukaemia development and anti-cancer immunity (Project Head Groß, Olaf )
• P07 - Modulation of the CNS innate immune system by the onco-metabolite (R)2-hydroxyglutarate in IDH1 mutant gliomas (Project Head Prinz, Marco )
• P08 - Manipulating STING signalling pathways in VHL mutant renal carcinoma cells to regulate T cell function (Project Head Frew, Ian )
• P10 - Targeting the pro-oncogenic ER-stress mediator ATF6 to reset the immunosuppressive tissue-microenvironment in liver cancer (Project Heads Heikenwälder, Mathias ;  Hofmann, Maike )
• P12 - The role of oncogene induced Oncostatin M in reprogramming the stem cell niche and promoting immune escape of leukaemia (Project Head Duyster, Justus )
• P13 - The role of HRAS downstream signalling for the production of immunosuppressive metabolites in the microenvironment of HRAS-driven SCC (Project Heads Kiritsi, Dimitra ;  Nyström, Alexander )
• P14 - Overcoming immune evasion of BRAF mutant colorectal cancer (Project Head Brummer, Tilman )
• P15 - Targeting oncogenic hubs of solid tumours to overcome immune evasion from adoptive T cell transfer (Project Head Minguet, Ph.D., Susana )
• P16 - Understanding the crosstalk between juvenile myelomonocytic leukaemia (JMML) and immune cells (Project Heads Bengsch, Ph.D., Bertram ;  Erlacher, Miriam )
• P17 - Targeting KRAS-driven tumours via their dependence on PTPN11/SHP2-phosphatase to enhance anti-tumour immunity (Project Head Ruess, Dietrich )
• S01 - S1: Data analysis, integration, and modelling (Project Heads Börries, Melanie ;  Köttgen, Anna ;  Schilling, Oliver )
• S02 - S2: Preclinical Imaging and NMR Spectroscopy (Project Heads Reichardt, Wilfried ;  Zeiser, Robert )
• Z01 - Serviceprojekt (Project Head Zeiser, Robert )
• Z02 - INF: Information Infrastructure for Research Data Management (Project Head Binder, Harald )
• Z03 - Integrated Research Training Group (IRTG) for Oncogene-driven immune escape (Project Head Börries, Melanie )

• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Spokesperson: Professor Dr. Robert Zeiser