Effects of cKit-D816V and FLT3-ITD on tissue factor-mediated immune escape in acute myeloid leukaemia (P03)

• Subject Area: Hematology, Oncology ; Clinical Immunology and Allergology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 441891347

This project will dissect how oncogenic FLT3-ITD and cKIT-D816V drive tissue factor (TF) expression to promote immune escape in AML. We will first elucidate the oncogenic signalling pathways downstream of FLT3-ITD and cKIT-D816V that drive TF expression in AML cells. We will then analyze the mechanisms by which TF mediates immune escape of leukaemia cells in vitro and in vivo. Finally, we will validate our findings from mouse models in human AML using GWAS, mass cytometry, microclot assays and kinase inhibition approaches.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1479: Oncogene-driven immune escape (OncoEscape)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professorin Priscilla Briquez, Ph.D., since 1/2026; Professorin Dr. Natalie Köhler