Project Details
Projekt
Engineering tissue-resident lymphocytes for the modulation of tissue-microenvironments (B03)
Subject Area
Immunology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 452881907
Tissue-resident lymphocytes (TRL) can seed, persist and function in distinct tissue-environments, which they can modulate to facilitate local immune responses. In this project, we will establish engineering approaches for the generation of TRL-like cells for adoptive cell therapy. We will systematically interrogate and validate TRL-specific genes using CRISPR/Cas9-mediated screening. We will additionally explore the ability of engineered ILCs to modulate local environments through the targeted delivery of cytokines. The potential of these novel cell engineering strategies will be validated in experimental models of infection and tumor, and in human T cells.
DFG Programme
CRC/Transregios
Applicant Institution
Technische Universität München (TUM)
Project Head
Professor Dr. Georg Gasteiger
