Project Details
Projekt
Metabolic reprogramming to optimize the cellular fitness and function of engineered T cells (C05)
Subject Area
Immunology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 452881907
Enhancement of stemness, persistence, and efficacy of (CAR or TCR) T cell products through innovative metabolic-epigenetic engineering strategies. This will be anticipated and tested by modulating ACLY-mediated protein acetylation, optimizing amino acid utilization capacity, as well as targeting death receptor and ROS signaling pathways. In addition, it will be tested whether hypothermic conditions can be used to optimize CAR T cell products regarding cellular fitness, subset composition and functionality, and whether patient specific metabolic factors such as obesity and diabetes mellitus can affect the function and toxicity of CAR-T cell therapy.
DFG Programme
CRC/Transregios
Applicant Institution
Technische Universität München
Project Heads
Professor Dr. Sebastian Theurich; Dr. Martin Vaeth
