Mechanistic Insights into tRNA Guanosine Modifications m1G and m7G (A01)

• Subject Area: General Genetics and Functional Genome Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 439669440

A01 investigates the role of tRNA guanosine modifications (m1G and m7G), formed by METTL1 and TRMT5, in regulating mRNA translation in cancer cells. By integrating advanced chemical biology, proteomics, and both in vitro and in vivo assays, the project will unravel the catalytic and non-catalytic functions of these enzymes in RNA processing and protein synthesis. Ultimately, the study aims to reveal how these tRNA modifications contribute to tumor growth and treatment resistance.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 319: RMaP: RNA Modification and Processing
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Dr. Fabian Barthels; Professorin Michaela Frye, Ph.D., since 7/2021; Professor Dr. Frank Lyko, from 7/2021 until 12/2025; Professorin Dr. Tanja Schirmeister, from 7/2021 until 12/2025