TRR 319:  RMaP: RNA Modification and Processing

• Subject Area: Biology ; Medicine
• Term: since 2021
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 439669440

No abstract available

• DFG Programme: CRC/Transregios

Current projects

• A01 - Mechanistic Insights into tRNA Guanosine Modifications m1G and m7G (Project Heads Barthels, Fabian ;  Frye, Ph.D., Michaela ;  Lyko, Frank ;  Schirmeister, Tanja )
• A02 - The biological relevance of NAD+-capping of RNA (Project Head Jäschke, Andres )
• A03 - How RNA modifications affect RNA processing and TLR8 stimulation in innate immune cells (Project Heads Butter, Falk ;  Dalpke, Alexander ;  Höbartner, Claudia )
• A04 - Ensemble analysis of mRNA editing, modification and processing in macrophages (Project Heads Papavasiliou, Ph.D., F. Nina ;  Stoecklin, Georg )
• A05 - Dynamics of modifications and processing of RNAs in the flavivirus replication cycle (Project Heads Helm, Mark ;  Ruggieri, Ph.D., Alessia )
• A06 - Interplay between tRNA processing and tRNA modifications (Project Heads Peschek, Jirka ;  Tuorto, Ph.D., Francesca )
• A07 - Uncovering the role of m¹A methylation in mitochondrial mRNA stability, translation, and function (Project Heads Friedland, Kristina ;  Gerber, Ph.D., Susanne )
• A08 - A08 How VIRMA Shapes m6A-Driven Transcript Modifications (Project Heads Frye, Ph.D., Michaela ;  Hengesbach, Martin )
• B03 - Molecular insights into the role of MTREC in ncRNA processing and degradation (Project Head Sinning, Irmgard )
• B04 - Schlafen-related nucleases in worms and man (Project Head Ketting, Ph.D., René )
• B07 - Mechanistic studies on the interplay of rRNA modification and processing with ribosome biogenesis, structure and function (Project Heads Butto, Ph.D., Tamer ;  Sinning, Irmgard ;  Winz, Marie-Luise )
• B08 - The role of P-bodies in m6A-mediated RNA decay (Project Heads König, Ph.D., Julian ;  Lyko, Frank )
• C01 - Novel modification mapping techniques and their application to single cell epitranscriptomics (Project Heads Helm, Mark ;  Hildebrandt, Andreas ;  Saunders, Lauren ;  Schmidt, Bertil )
• C02 - Sci-ModoM - the lighthouse database of transcriptome-wide RNA modification and processing (Project Heads Dieterich, Christoph ;  Hildebrandt, Andreas )
• C03 - Mass spectrometry of RNA and proteins in modified RNPs (Project Heads Beli, Petra ;  Butter, Falk ;  Helm, Mark ;  Jäschke, Andres )
• C04 - Precision Nanopore sequencing of RNA modifications and processing events (Project Heads Dieterich, Christoph ;  Gerber, Ph.D., Susanne )
• IRTGMGK - Integrated Research Training Group “Young Researchers in RNA Modification and Processing” (YouRMaP) (Project Head Ruggieri, Ph.D., Alessia )
• Z - Central Task of the Collaborative Research Center (Project Head Helm, Mark )

Completed projects

• B01 - The mechanistic and functional impact of RNA modifications on alternative splicing (Project Heads Dieterich, Christoph ;  König, Ph.D., Julian ;  Roignant, Jean-Yves )
• B05 - Mismodification of tRNA in no-go decay and other co-translational quality control pathways (Project Head Winz, Marie-Luise )
• B06 - Assembly, activity, and structural dynamics in eukaryotic H/ACA complexes (Project Head Hengesbach, Martin )

• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Co-Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Participating University: Julius-Maximilians-Universität Würzburg
• Participating Institution: Deutsches Krebsforschungszentrum (DKFZ)
• Spokesperson: Professor Dr. Mark Helm