Mismodification of tRNA in no-go decay and other co-translational quality control pathways (B05)

• Subject Area: Biochemistry
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 439669440

tRNAs are heavily modified to aid function in translation and the lack of various modifications leads to aberrations in translation and aggregation of resulting proteins. Co-translational quality control detects and resolves various translation defects, including ribosome collisions. Here, a link between both phenomena will be explored by determining whether lack of specific tRNA modifications leads to ribosome collision, whether translation defects caused by lack of tRNA modifications are sensed and resolved by co-translational quality control machinery, and finally, whether this (partially) counteracts resulting protein aggregation.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 319: RMaP: RNA Modification and Processing
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Head: Professorin Dr. Marie-Luise Winz