Ensemble analysis of mRNA editing, modification and processing in macrophages (A04)

• Subject Area: General Genetics and Functional Genome Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 439669440

Macrophages are important cells of the innate immune system and require modification of adenosine in messenger RNA (mRNA) to fulfill their functions. Project A04 interrogates the interplay and interdependency between adenosine to inosine deamination and N6-adenosine methylation in the mouse macrophage cell line RAW264.7. We focus on the effect of these modifications on nuclear mRNA processing including splicing and polyadenylation site selection, as well as their role in transcription-dependent control of mRNA turnover.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 319: RMaP: RNA Modification and Processing
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professorin F. Nina Papavasiliou, Ph.D.; Professor Dr. Georg Stoecklin