Interplay between tRNA processing and tRNA modifications (A06)

• Subject Area: Biochemistry
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 439669440

The maturation of transfer RNAs (tRNAs) involves the intricate interplay between processing and modification steps. We aim to dissect the molecular mechanisms that coordinate these events during tRNA biosynthesis. To this end, we will map the modification status of pre-tRNAs at distinct maturation stages. Moreover, we will elucidate the hierarchical interdependencies and structures of key enzyme complexes, their subcellular localization, and the biological roles of tRNA introns.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 319: RMaP: RNA Modification and Processing
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Dr. Jirka Peschek; Dr. Francesca Tuorto, Ph.D.