Project Details
Projekt
The mechanistic and functional impact of RNA modifications on alternative splicing (B01)
Subject Area
General Genetics and Functional Genome Biology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 439669440
N6-methyladenosine (m6A) affects almost every stage of mRNA metabolism, including alternative splicing, and its alteration is associated with various physiological defects and diseases. Here, all m6A-dependent splicing events and all m6A sites that affect splicing will be mapped. The mechanistic interplay of effector proteins and the role of cis-regulatory elements that influence m6A-mediated regulation will be evaluated and links to RNA-binding proteins tested. This work will use Drosophila and human cells to work out conservation and differences and will be extended to the potential roles of other RNA modifications in alternative splicing regulation.
DFG Programme
CRC/Transregios
Subproject of
TRR 319:
RMaP: RNA Modification and Processing
Applicant Institution
Johannes Gutenberg-Universität Mainz
