Autonomous chemical and cell-based sensor-actuator systems for the detection and combat of implant-associated infections (B01)

• Subject Area: Dentistry, Oral Surgery ; Preparatory and Physical Chemistry of Polymers
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 426335750

Subproject B01 covers the entire range from the detection of peri-implant infections to the autoregulatory reaction and thus has model character for project area B. Chemical and cellular sensor-actuator systems are being developed that release anti-biofilm agents via synthetic regulatory cassettes in response to infection-specific signals. To increase specificity, sensitivity, and therapeutic efficacy, cellular systems will be refined utilizing innovative signal amplification strategies and coupled with tailored chemical systems. Personalized 3D tissue-implant-biofilm models will be developed to enable in-depth characterization and validation of the systems, as well as to assess patient-specific factors influencing disease detection and treatment efficacy.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 298: Safety Integrated and Infection Reactive Implants
• Applicant Institution: Medizinische Hochschule Hannover
• Project Heads: Professor Dr. Henning Menzel; Professorin Dr. Meike Stiesch; Professorin Dr. Dagmar Wirth