Active stimulus-responsive implants (B04)

• Subject Area: Biomaterials ; Metallurgical, Thermal and Thermomechanical Treatment of Materials
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 426335750

Subproject B04 aims to develop physician-controlled activatable reaction systems, which release active substances to combat infections in a targeted manner in the event of clinical signs of infection. For this purpose, switchable miniaturised electromagnetic pumps will be integrated into the implant body, which guide the active ingredient via a channel system through a biocompatible porous coating, to be released on the implant surface. In order to ensure high cyclic mechanical strength of these implant systems, new ultra-fine grain (UFG) materials based on niobium-zirconium are to be developed. Material and biological testing will be performed in specific biomechanical test rigs and biofilm models.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 298: Safety Integrated and Infection Reactive Implants
• Applicant Institution: Medizinische Hochschule Hannover
• Project Heads: Dr.-Ing. Christian Klose; Professor Dr.-Ing. Hans Jürgen Maier; Privatdozent Dr. Philipp-Cornelius Pott