Regulation of synaptic functional heterogeneity and diversity (A11)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

Aiming to identify molecular principles that confer synaptic diversity and heterogeneity, we used the previous funding period to map the protein organization in presynaptic sub-compartments, including the active zone and the synaptic vesicle membrane. Based on these findings, we will refine the presynaptic proximity map, and to test the hypothesis that the function and expression of key signalling proteins shapes synaptic transmission properties.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Noa Lipstein-Thoms, Ph.D.