The synapse as a complex physical environment (C05*)

• Subject Area: Bioinformatics and Theoretical Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

The synapse is a complex environment, as it is densely packed and has a complex geometry, structured by internal membranes. All these structural aspects affect the mobility of proteins in the synapse, and thus their delivery to the active zone, where most of the proteins execute their functions. In this project, we will dissect the contributions of the different physical features of synapses to investigate their impact on protein mobility, working towards an understanding of how they shape synaptic function, relying on dynamic Monte Carlo simulations.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Stefan Klumpp