Coarse-grained simulation of the role of local environment on presynaptic release: from fusion to fission (C06)

• Subject Area: Statistical Physics, Nonlinear Dynamics, Complex Systems, Soft and Fluid Matter, Biological Physics
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

Our previous work identified key environmental factors that prevent the radial expansion of the fusion pore and the subsequent collapse of the SV into the plasma membrane. In this period, we will focus on the role of proteins, such as SNAREs and dynamins. We will investigate synaptic release mechanisms, varying the number and placement of proteins, and compare our results to ultrastructural and fluorescence imaging experiments, from other projects within CRC1286.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Marcus Müller