Experimental and theoretical analysis of single active zone function (C08)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Biophysics ; Experimental and Theoretical Network Neuroscience
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

We the rod photoreceptor active zone as an excellent model to 1) assess the molecular topology of Ca2+ channels and synaptic vesicle release sites, and 2) to study active zone function with electrophysiology. 1. In the third funding period, we will quantify numbers and relative topography of calcium channels, active zone proteins and synaptic vesicle proteins by 3D-MINFLUX, and we will test our hypothesis that calcium channels exert a nanodomain control on synaptic vesicle release.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Tobias Moser