Relating the presynaptic vesicle cycle to the information processing function of synaptic plasticity (C09*)

• Subject Area: Experimental and Theoretical Network Neuroscience
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

Neural communication relies on neurotransmitter release and is therefore heavily influenced by the dynamics of synaptic vesicles. We generated a model of the presynaptic vesicle cycle, which combines experimental findings from several stages of the vesicle cycle and enables us to assess the dependence of vesicle release on synaptic input over multiple timescales, from milliseconds to hours. We now propose to build on this model and relate its parameters to the short-term dynamics of vesicle release, to understand how short-term plasticity arises, and how it relates to neuronal function.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professorin Dr. Viola Priesemann