Project Details
Projekt
Molecular guided experimental treatments in patients with relapsed/ refractory lymphoid malignancies
Applicants
Privatdozent Dr. Martin Neumann; Dr. Annika Rademacher
Subject Area
Hematology, Oncology
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 444949889
The project will continue to create a clinical platform and a center of excellence for both children and adults suffering from ALL and experiencing multiple relapses. The CATCH ALL Board will further expand as platform for discussion between all projects of the CRU (P1-8 and INF). Preclinical data, both in vitro and in vivo, will be generated for new antibodies through drug screening and PDX approaches (collaboration P6 and P7). Lastly, the project will incorporate age-appropriate educational initiatives for students and clinician-scientists under a common logo (CATCH ALL School). With the increasing availability of immunotherapies, characterization of surface protein expression enables individualized treatment recommendation in patients with otherwise no available standard treatment option. For this, in co-operation with project P3 a flow panel will be established. As T-ALL remains the ALL subentity with few treatment modalities we will explore the diversity of molecular make-up with own and publicly available data sets to build a robust T-ALL classifier (collaboration with P1, P4, INF).
DFG Programme
Clinical Research Units
