Ein Ernährungsmuster zur Flavonolaufnahme als Risikofaktor für Pankreaskrebs in der Multiethnic Cohort Study und der EPIC-Studie
Final Report Abstract
Based on our prior finding of inverse associations between flavonols and pancreatic cancer (1) we aimed at (a) defining a food pattern associated with the intake of quercetin, kaempferol and myricetin, and (b) examining associations of the food pattern with pancreatic cancer risk, and (c) confirming associations of a simplified food pattern with pancreatic cancer in an independent study population. The research project aimed at doing this with a unique international approach. Reduced rank regression (RRR) was applied to dietary data for 183,513 participants in the Multiethnic Cohort Study (MEC) at the Cancer Research Center of Hawaii. A food group and a food item pattern were extracted and simplified, and applied to dietary data of 424,978 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC-Study). Multivariate Cox proportional hazards models were used to estimate relative risks for pancreatic cancer in the MEC (610 cases) and the EPIC-Study (517 cases) with the food patterns. The food group pattern consisted mainly of black tea, fruit, cabbage and wine, and the food item pattern was similar. In MEC, inverse associations with pancreatic cancer in smokers were observed for the food group (RR 0.61 (95% Cl 0.32-1.13) comparing extreme quintiles, p trend = 0.04) and slightly stronger for the food item pattern (0.47 (0.24-0.93), p trend = 0.04). In the EPIC study, the simplified pattern was not associated with pancreatic cancer risk (p trend = 0.70). Our study gives evidence for a pancreatic cancer preventive effect of a food pattern associated with intake of quercetin, kaempferol and myricetin in smokers. However, the associations of the food pattern could not be confirmed in an independent study, and further research to elucidate the associations is warranted.
