Project Details
Projekt
Dynamics and Intermediates of DNA Base Modification Processes (A04)
Subject Area
Biological and Biomimetic Chemistry
Term
from 2007 to 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 27112786
Project A04 investigates the mechanisms that are involved in the formation and repair of DNA lesions, which are mostly modified DNA bases. DNA lesions are for example formed upon reaction of electrophilic nitrenium ions with DNA or when DNA is exposed to UV-light. We investigate the mechanism that lead to the formation of DNA lesions and we try to understand the processes that allow repair enzymes to remove the lesions from the genome. Some modified DNA bases, such as Hydroxymethylcytosine, Formylcytosine und Carboxycytosine are generated by special enzymes. We study the mechanisms that lead to their formation and the function of the new bases.
DFG Programme
Collaborative Research Centres
Applicant Institution
Ludwig-Maximilians-Universität München
Project Head
Professor Dr. Thomas Carell
