Self-resistance mechanisms of actinomycetes producing antibiotics targeting peptidoglycan biosynthesis (A03)

• Subject Area: Parasitology and Biology of Tropical Infectious Disease Pathogens
• Term: from 2007 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 32152271

Producers of glycopeptides and lantibiotics have developed so far unknown mechanisms by which they protect their cell envelope against their own products. In A3, we will investigate the alternative metabolic pathways that are used to synthesize glycopeptide resistant peptidoglycan precursors and which mediate resistance to the lantibiotic NAI-107. In particular, we will determine the relevance of unusual peptidoglycan cross-linking, which are catalyzed by L,D-transpeptidases, for the resistance.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 766: The Bacterial Cell Envelope: Structure, Function and Infection Interface
• Applicant Institution: Eberhard Karls Universität Tübingen
• Project Head: Privatdozentin Efthimia Stegmann, Ph.D.