Investigating chromosome movement during meiotic prophase I

• Applicant: Professor Dr. Arp Schnittger
• Subject Area: Plant Genetics and Genomics ; Plant Cell and Developmental Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 490729328

Meiosis is a key step in reproduction during which homologous recombination not only ensures genome stability (DNA repair, correct segregation of the homologous chromosomes in gametes) but also promotes genetic diversity (generation of new allelic combinations). Already many years ago, it was recognized that meiotic chromosomes are highly mobile and their movements have been implicated in recombination. However, due to the lack of appropriate imaging set up, little is known about chromosome dynamics. In their preparatory work, the partners of this initiative have established a system to follow Arabidopsis thaliana chromosomes in real time. In addition, this consortium unites researchers experienced in quantitative image analysis and modeling next to experts in meiotic recombination and cytogenetics studies. Combining these expertises will allow us to describe chromosome dynamics in meiosis with unprecedented resolution and assess its importance for recombination.

• DFG Programme: Research Grants
• International Connection: France
• Cooperation Partners: Dr. Philippe Andrey; Professorin Dr. Mathilde Grelon