The role of ferroptosis in diffuse large B-cell lymphoma subtypes (B03)

• Subject Area: Cell Biology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 455784452

Ferroptosis is an iron-dependent form of regulated necrosis, resulting from the collapse of cellular antioxidant defense systems. Recently, it was shown that ferroptosis represents an exquisite vulnerability in diffuse large B cell lymphoma (DLBCL) in direct comparison to other cancer entities. Therefore, this project will provide an in-depth characterization of the in vivo role of ferroptosis induction in high-risk DLBCL and mechanistic underpinnings important for efficacy. Insights obtained will be used towards providing rationale for clinical repurposing of compounds inducing ferroptotic cell death for the treatment of high-risk DLBCL.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1530: Elucidation and targeting of pathogenic mechanisms in B cell malignancies
• Applicant Institution: Universität zu Köln
• Project Head: Professorin Dr. Silvia von Karstedt