Sterile inflammation and innate immunity in HFpEF (A07)

• Subject Area: Cardiology, Angiology ; Cell Biology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 437531118

Low-grade inflammation induced by comorbidities is recognized to underlie HFpEF-specific remodelling. S100A8/A9 and the NLRP3 inflammasome are important contributors to sterile inflammation and splenic monocytopoeisis in the comorbidities associated with HFpEF. The projects explores the role of innate immunity in HF, evaluating whether systemic vs. cardiac deregulation of the alarmin S100A9 and NLRP3 inflammasome activity triggers HFpEF vs. HFrEF and how this influences splenic activity and potentially the cardiosplenic axis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1470: Multilevel mechanistic characterisation of Heart Failure with Preserved Ejection Fraction - Towards a novel classification of HFpEF for targeted therapies
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Head: Professorin Dr. Sophie van Linthout, Ph.D.