Project Details
Projekt
Development and characterisation of additively manufactured patient-specific dental implants
Subject Area
Dentistry, Oral Surgery
Biomaterials
Biomaterials
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 449916462
The objectives of subproject 4 in the first funding period were the development of a finite element (FE) model for patient-specific graded dental implants (digital implant), the development of a strategy for the surface functionalization of additively manufactured implants, and the development or use of innovative in-vitro model systems for the characterization of the implants regarding biomechanical and biological properties. The goal in funding period 2 will be to develop additively manufactured dental implants that are specifically optimized for various superstructures and stages of bone resorption, support by finite element analysis. An important question is how to achieve the most favorable biomechanical loads on the peri-implant bone over the lifespan of the implant. Furthermore, it will be investigated what influence the lattice structures have on the loading of the peri-implant bone and the mechanical properties of the implant. To validate this, a methodology for the parameterized creation of CAD bone models will be developed, which will serve to create physical bone models that will help validate the FE simulations. Additionally, for the successful use of implants, the implant-tissue interaction is crucial, which will be optimized here through surface functionalization using Mg coatings to enhance biological integration and minimize the risk of infection. The resulting Mg coatings will be analyzed in detail in complex in-vitro models (bacteria, biofilm, cell, and co-culture analyses).
DFG Programme
Research Units
