Project Details
Projekt
Autoantigen-specific T cells in pemphigoid diseases (A01)
Subject Area
Immunology
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 454193335
Pemphigoid diseases (PDs) are chronic antibody-induced autoimmune diseases (AADs). Autoantigen-specific T helper cells are thought to be centrally involved in the pathogenesis of PDs but remain poorly understood. We have developed antigen-reactive T cell enrichment (ARTE) as a powerful technology for unbiased identification and characterization of autoantigen-specific CD4 regulatory (Tregs) and conventional T cells (Tcon.). A01 will employ ARTE for in-depth characterization of autoreactive T cells from healthy donors and PD patients. Pathogenic and therapeutic T cell functions will be tested in a relevant mouse model.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1526:
Pathomechanisms of Antibody-mediated Autoimmunity (PANTAU): Insights from Pemphigoid Diseases
Applicant Institution
Universität zu Lübeck
Project Heads
Professor Dr. Alexander Scheffold; Professor Dr. Enno Schmidt
