Characterization and targeted modulation of the gut - skin axis in pemphigoid diseases (B07)

• Subject Area: Gastroenterology ; Clinical Immunology and Allergology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 454193335

Recent clinical and experimental evidence suggests a critical role of gut microbiota in modulating systemic immune cell functions and inflammatory responses. Yet, their involvement in pemphigoid diseases (PDs) has not been investigated. In this project, we aim to examine the connection between gut microbiota and skin inflammation using human PD patient biomaterial and murine PD models. A second major aim is to identify gut microbe-derived mediators as potential therapeutic options for PDs.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1526: Pathomechanisms of Antibody-mediated Autoimmunity (PANTAU): Insights from Pemphigoid Diseases
• International Connection: United Arab Emirates
• Applicant Institution: Universität zu Lübeck
• Project Heads: Professor Dr. John F. Baines; Professor Dr. Saleh M. Ibrahim