Controlling the suppressive and regeneration programs in tumor-resident tissue Treg cells (19)

• Subject Area: Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 318346496

We established single-cell sequencing protocols to investigate tissue-derived T cells and found shared molecular programs in tumor Treg cells and healthy tissue Treg cells. We generated tissue-like Treg cells in-vitro and performed a secretome screening, identifying proteins involved in immune regulation, matrix remodeling, tissue regeneration, and immune cell recruit-ment. In the new funding period, we aim to understand how these tissue Treg-produced factors promote tissue regeneration and whether they contribute to tumor growth and metastasis in the cellular and anatomical tissue context.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1292: Targeting convergent mechanisms of inefficient immunity in tumors and chronic infections
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Michael Delacher; Dr. Federico Marini