Induction of a tissue repair program as a strategy for immune evasion in tumors and chronic infections (19*)

• Subject Area: Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 318346496

Regeneration is pivotal for the maintenance and repair of tissues upon damage. Our previous work identified a population of regulatory T (Treg) cells with tissue repair capacity. The contribution of this Treg subpopulation to immune evasion in the context of chronic infections and tumors is unclear. This proposal aims elucidate the impact of inflammation, disease development and tissue age on the induction and persistence of tissue repair Treg cells, using a combination of single cell resolution molecular assays. In addition, the contribution of this cell type to immune evasion will be studied in animal models of infection and cancer.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1292: Targeting convergent mechanisms of inefficient immunity in tumors and chronic infections
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Michael Delacher; Dr. Federico Marini