The effects of aging on glial cells of the brain: implications for physiological functions (A04)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450627322

In this proposal (A04) we are aiming at studying the effects of aging in myelination and at deciphering the potential of therapeutic approaches to overcome the age dependent decrease in oligodendrogenesis in order to improve cognitive decline in aged animals. The combination of these approaches will help to get novel information on the role of myelination in aging and the identification of novel approaches that could be therapeutically addressed in the future. We therefore propose a/ voluntary physical activity and b/ targeting the receptor GPR17, to improve myelination and cognitive performance in aged animals.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1506: Aging at Interfaces
• Applicant Institution: Universität Ulm
• Project Head: Professorin Dr. Leda Dimou