Project Details
Projekt
Epigenetic clocks, blood-based biomarkers and functional parameters for the estimation of biological age (C06)
Subject Area
Cell Biology
General Genetics and Functional Genome Biology
Epidemiology and Medical Biometry/Statistics
Biogerontology and Geriatric Medicine
General Genetics and Functional Genome Biology
Epidemiology and Medical Biometry/Statistics
Biogerontology and Geriatric Medicine
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 450627322
There is an unmet need to find an adequate model for biological age. In this project, we use the well characterized ActiFE cohort to develop a model for biological age based on blood-based biomarkers, relevant clinical and functional parameters, and targeted epigenetic clocks. The analysis will also integrate new concepts based on DNA methylation analysis. In a translational approach we will examine epigenetic clocks also in mice. Our joint research will investigate the interface between biological age, frailty, and epigenetic aging to provide a new construct for biological age assessment.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1506:
Aging at Interfaces
Applicant Institution
Universität Ulm
