Dynamic and spatiotemporal control of Notch signaling for assembling precise multicellular structures (A14*)

• Subject Area: Biochemistry
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 386797833

The assembly of new tissues from the bottom-up starting from single cells is a powerful approach to tissue engineering. Here, we will develop a light controlled version of the Notch signaling, named optoNotch, for building multicellular structures, dynamically control contact dependent cell to cell signaling with high precision in space and time and investigate the interplay with cell-cell adhesions. This will pave the way to rationally program cell signaling pathways that direct the formation of desired multicellular architectures.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1348: Dynamic cellular interfaces: formation and function
• Applicant Institution: Universität Münster
• Project Head: Professorin Dr. Seraphine Wegner