Project Details
Projekt
Dynamic and spatiotemporal control of Notch and Plexin signaling for assembling precise multicellular structures (A14)
Subject Area
Biochemistry
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 386797833
The bottom-up assembly of new tissues starting from single cells is a powerful approach in tissue engineering. Here, we will develop light-controlled versions of Notch and Plexin signaling, two key pathways involved in tissue organization. By combining these optogenetic tools with micropatterned biomimetic surfaces, we aim to investigate how receptor-ligand interaction dynamics and clustering impact on signaling and cell-cell adhesions. This approach will allow us to uncover the role of Plexin signaling in tumor microenvironments and cancer metastasis, and to rationally guide the formation of 3D multicellular structures.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Münster
Project Heads
Dr. Maria Florencia Sánchez, since 1/2026; Professorin Dr. Seraphine Wegner
