Remodeling of tricellular junctions controls paracellular transport (B11*)

• Subject Area: Cell Biology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 386797833

During oogenesis in oviparous animals, tricellular junctions in the follicular epithelium open transiently to allow passage of yolk proteins for uptake by the oocyte. We will study this process, referred to as patency, using Drosophila as a model system to understand how the dynamic remodeling of adhesion complexes at the interface between three cells controls epithelial permeability. We will investigate how the regulation of endocytosis, actomyosin contractility and of cell volume mediate transient opening of cell vertices.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1348: Dynamic cellular interfaces: formation and function
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Stefan Luschnig