Remodeling of tricellular junctions controls paracellular transport (B11)

• Subject Area: Cell Biology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 386797833

During oogenesis in oviparous animals, tricellular junctions (TCJs) in the follicular epithelium open transiently to allow passage of yolk proteins for uptake by the oocyte. This process involves remodeling of adhesion complexes and of actomyosin at cell vertices and is regulated by TGF-β signaling. We aim to identify the relevant TGF-β effectors that control actomyosin and E-Cadherin dynamics. To understand how the barrier-forming complex is assembled at the interface of three cells, we will investigate the structure of the TCJ protein Anakonda (Aka).

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1348: Dynamic cellular interfaces: formation and function
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Stefan Luschnig