EXC 306:  Entzündungen an Grenzflächen

• Fachliche Zuordnung: Mikrobiologie, Virologie und Immunologie
• Förderung: Förderung von 2007 bis 2018
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 49701054

• Erstellungsjahr: 2019

Zusammenfassung der Projektergebnisse

Chronisch entzündliche Barrierekrankheiten (CIBD) stellen wegen ihrer Komplexität, ihren systemischen Effekten auf den Organsimus und der Interaktion zwischen Umwelt und Genen eine große Herausforderung dar. Die erste Förderperiode (FP-1) des Clusters gestaltete das hypothetische Krankheitsmodell den Forschungsprozess linear von einigen wenigen erwarteten Krankheitsgenen bis hin zur Struktur und zur evolutionären und funktionellen Annotation. Die beispiellose Komplexität der ätiologischen Befunde führte in der zweiten Förderperiode (FP-2) zu einem anderen Ansatz. Hier wurde unsere Suchstrategie mit Research Areas weiterentwickelt, um tiefgehende genetische, genomische und funktionelle Schlüsselkomponenten von Entzündungskrankheiten in Interaktion mit den Cluster-Laboren zu untersuchen. Der Cluster “Inflammation at Interfaces“ vereinte die Expertise und (inter-)nationale Kooperationen eines einzigartigen multidisziplinären Teams von >250 Wissenschaftlerinnen und Wissenschaftlern aus zehn Disziplinen, um die Erforschung der CIBD voranzutreiben. Eine wichtige Errungenschaft des letzten Jahrzehnts ist ein tiefgreifender Wandel der wissenschaftlichen Kultur und Governance aller am Cluster beteiligten Institutionen/Fakultäten, der zu einer signifikanten Steigerung der wissenschaftlichen Produktivität und Sichtbarkeit beigetragen hat. Unsere lokale Entwicklung ist einzigartig in seiner Interdisziplinarität und der starken Konzentration auf die klinische Übersetzung. Dies umfasst eine kritische Masse im interdisziplinären Patientenzugang über den gesamten Bereich der CIBD, einschließlich der Reorganisation der Versorgung von Entzündungspatienten verschiedener Subspezialitäten in den Exzellenzzentren für Entzündungsmedizin (CCIM). Diese Zentren unterstützen große Kohorten und therapeutische Studien. Die aus der strukturellen Innovation resultierende interdisziplinäre Forschungskultur hat zu einer herausragenden Menge von Ergebnissen geführt. Beispielsweise waren Cluster-Wissenschaftlerinnen und -Wissenschaftler in mehreren internationalen genetischen Metaund GWAS-Analysen für CIBD involviert oder haben diese Projekte geleitet. Ein weiterer Höhepunkt der Entwicklung dieses Clusters war die Entwicklung eines IL-6 Trans- Signalinhibitors, der derzeit in einer Phase-2-Studie für CIBD getestet wird. Der derzeitige Cluster "Precision Medicine in Chronic Inflammation" (PMI) zielt darauf ab, eine individuelle molekulare Wirksamkeitssignatur für Therapien bei Patienten zu beschreiben, die zukünftig für die individuelle Auswahl entzündungshemmender Therapien eine entscheidende Rolle spielen wird. Der Aufbau einer medizinischen Systembiologie und eine massive Investition in die IT waren wichtige Vorraussetzungen und Errungenschaften der zweiten Förderperiode. Das ultimative Ziel von PMI ist es, entzündliche Barrierekrankheiten im frühen, noch nicht klinischen Stadium nach Erreichen eines Point-of-no-return zu definieren und rationale Interventionen zu entwickeln.

Link zum Abschlussbericht

https://dx.doi.org/10.2314/KXP:1697278027

Projektbezogene Publikationen (Auswahl)

• (2007). A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease. Nat Genet. 39(8):995-9
  Buch S, Schafmayer C, Völzke H, Becker C, Franke A, von Eller-Eberstein H, Kluck C, Bässmann I, Brosch M, Lammert F, Miquel JF, Nervi F, Wittig M, Rosskopf D, Timm B, Höll C, Seeger M, ElSharawy A, Lu T, Egberts J, Fändrich F, Fölsch UR, Krawczak M, Schreiber S, Nürnberg P, Tepel J, Hampe J
  
• (2007). A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet. 39(2):207-11
  Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G, De La Vega FM, Briggs J, Günther S, Prescott NJ, Onnie CM, Häsler R, Sipos B, Fölsch UR, Lengauer T, Platzer M, Mathew CG, Krawczak M, Schreiber S
  
• (2007). Certolizumab pegol for the treatment of Crohn's disease. N Engl J Med. 357(3):228-38
  Sandborn WJ, Feagan BG, Stoinov S, Honiball PJ, Rutgeerts P, Mason D, Bloomfield R, Schreiber S; PRECISE 1 Study Investigators
  
• (2007). Genomewide association analysis of coronary artery disease. N Engl J Med. 357(5):443-53
  Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, König IR, Stevens SE, Szymczak S, Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien F, Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas P, Tobin MD, Ziegler A, Thompson JR, Schunkert H; WTCCC and the Cardiogenics Consortium
  
• (2007). LIMP-2 is a receptor for lysosomal mannose-6-phosphateindependent targeting of beta-glucocerebrosidase. Cell. 131(4):770-83
  Reczek D, Schwake M, Schröder J, Hughes H, Blanz J, Jin X, Brondyk W, Van Patten S, Edmunds T, Saftig P
  
• (2007). Maintenance therapy with certolizumab pegol for Crohn's disease. N Engl J Med. 357(3):239-50
  Schreiber S, Khaliq-Kareemi M, Lawrance IC, Thomsen OØ, Hanauer SB, McColm J, Bloomfield R, Sandborn WJ; PRECISE 2 Study Investigators
  
• (2007). Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature. 449(7162):564-9
  Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, Cao W, Wang YH, Su B, Nestle FO, Zal T, Mellman I, Schröder JM, Liu YJ, Gilliet M
  
• (2008). Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science. 319(5863):624-7
  Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H
  
• (2008). Emergence of extensive drug resistance during treatment for multidrugresistant tuberculosis. N Engl J Med. 359(22):2398-400
  Cox HS, Sibilia K, Feuerriegel S, Kalon S, Polonsky J, Khamraev AK, Rüsch-Gerdes S, Mills C, Niemann S
  
• (2008). Genome-wide association analysis in sarcoidosis and Crohn's disease unravels a common susceptibility locus on 10p12.2. Gastroenterology. 135(4):1207-15
  Franke A, Fischer A, Nothnagel M, Becker C, Grabe N, Till A, Lu T, Müller-Quernheim J, Wittig M, Hermann A, Balschun T, Hofmann S, Niemiec R, Schulz S, Hampe J, Nikolaus S, Nürnberg P, Krawczak M, Schürmann M, Rosenstiel P, Nebel A, Schreiber S
  
• (2008). Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. Nat Genet. 40(9):1103-6
  Hofmann S, Franke A, Fischer A, Jacobs G, Nothnagel M, Gaede KI, Schürmann M, Müller- Quernheim J, Krawczak M, Rosenstiel P, Schreiber S
  
• (2008). Regulatory networks define phenotypic classes of human stem cell lines. Nature. 455(7211):401-5
  Müller FJ, Laurent LC, Kostka D, Ulitsky I, Williams R, Lu C, Park IH, Rao MS, Shamir R, Schwartz PH, Schmidt NO, Loring JF
  
• (2008). Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nat Genet. 40(6):713-5
  Franke A, Balschun T, Karlsen TH, Hedderich J, May S, Lu T, Schuldt D, Nikolaus S, Rosenstiel P, Krawczak M, Schreiber S
  
• (2008). Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet. 40(11):1319-23
  Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, Sina C, Onnie CM, Weersma RK, Stokkers PC, Wijmenga C, Gazouli M, Strachan D, McArdle WL, Vermeire S, Rutgeerts P, Rosenstiel P, Krawczak M, Vatn MH; IBSEN study group, Mathew CG, Schreiber S
  
• (2008). XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 134(5):743-56
  Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH, Blumberg RS
  
• (2009). A common variant on chromosome 11q13 is associated with atopic dermatitis. Nat Genet. 41(5):596-601
  Esparza-Gordillo J, Weidinger S, Fölster-Holst R, Bauerfeind A, Ruschendorf F, Patone G, Rohde K, Marenholz I, Schulz F, Kerscher T, Hubner N, Wahn U, Schreiber S, Franke A, Vogler R, Heath S, Baurecht H, Novak N, Rodriguez E, Illig T, Lee-Kirsch MA, Ciechanowicz A, Kurek M, Piskackova T, Macek M, Lee YA, Ruether A
  
• (2009). New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet. 41(3):280-2
  Erdmann J, ..., et al.; Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group; Myocardial Infarction Genetics Consortium; Wellcome Trust Case Control Consortium; Cardiogenics Consortium
  
• (2009). Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature. 460(7259):1159-63
  Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pongratz C, Schramm M, Kleinridders A, Wunderlich T, Kashkar H, Utermöhlen O, Brüning JC, Schütze S, Krönke M
  
• (2010). A phylogenetically based transcriptome age index mirrors ontogenetic divergence patterns. Nature. 468(7325):815-8
  Domazet-Lošo T, Tautz D
  
• (2010). Autosomal-dominant striatal degeneration is caused by a mutation in the phosphodiesterase 8B gene. Am J Hum Genet. 86(1):83-7
  Appenzeller S, Schirmacher A, Halfter H, Bäumer S, Pendziwiat M, Timmerman V, De Jonghe P, Fekete K, Stögbauer F, Lüdemann P, Hund M, Quabius ES, Ringelstein EB, Kuhlenbäumer G
  
• (2010). Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med. 207(8):1617-24
  Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S
  
• (2010). Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). Nat Genet. 42(4):292-4
  Franke A, Balschun T, Sina C, Ellinghaus D, Häsler R, Mayr G, Albrecht M, Wittig M, Buchert E, Nikolaus S, Gieger C, Wichmann HE, Sventoraityte J, Kupcinskas L, Onnie CM, Gazouli M, Anagnou NP, Strachan D, McArdle WL, Mathew CG, Rutgeerts P, Vermeire S, Vatn MH; IBSEN study group, Krawczak M, Rosenstiel P, Karlsen TH, Schreiber S
  
• (2010). Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat Genet. 42(11):991-5
  Ellinghaus E, Ellinghaus D, Stuart PE, Nair RP, Debrus S, Raelson JV, Belouchi M, Fournier H, Reinhard C, Ding J, Li Y, Tejasvi T, Gudjonsson J, Stoll SW, Voorhees JJ, Lambert S, Weidinger S, Eberlein B, Kunz M, Rahman P, Gladman DD, Gieger C, Wichmann HE, Karlsen TH, Mayr G, Albrecht M, Kabelitz D, Mrowietz U, Abecasis GR, Elder JT, Schreiber S, Weichenthal M, Franke A
  
• (2010). Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet. 42(12):1118-25
  Franke A, ..., Parkes M
  
• (2010). In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides. Proc Natl Acad Sci USA. 107(42):18067-72
  Fraune S, Augustin R, Anton-Erxleben F, Wittlieb J, Gelhaus C, Klimovich VB, Samoilovich MP, Bosch TC
  
• (2011). Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype. Proc Natl Acad Sci USA. 108(47):19030-5
  Rausch P, Rehman A, Künzel S, Häsler R, Ott SJ, Schreiber S, Rosenstiel P, Franke A, Baines JF
  
• (2011). Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nat Genet. 43(1):17-9
  Melum E, Franke A, Schramm C, Weismüller TJ, Gotthardt DN, Offner FA, Juran BD, Laerdahl JK, Labi V, Björnsson E, Weersma RK, Henckaerts L, Teufel A, Rust C, Ellinghaus E, Balschun T, Boberg KM, Ellinghaus D, Bergquist A, Sauer P, Ryu E, Hov JR, Wedemeyer J, Lindkvist B, Wittig M, Porte RJ, Holm K, Gieger C, Wichmann HE, Stokkers P, Ponsioen CY, Runz H, Stiehl A, Wijmenga C, Sterneck M, Vermeire S, Beuers U, Villunger A, Schrumpf E, Lazaridis KN, Manns MP, Schreiber S, Karlsen TH
  
• (2011). Heat-shock protein 90 inhibition in autoimmunity to type VII collagen: evidence that nonmalignant plasma cells are not therapeutic targets. Blood. 117(23):6135-42
  Kasperkiewicz M, Müller R, Manz R, Magens M, Hammers CM, Somlai C, Westermann J, Schmidt E, Zillikens D, Ludwig RJ, Orosz A
  
• (2011). Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 43(4):333-8
  Schunkert H, ..., CARDIoGRAM Consortium, Samani NJ
  
• (2011). Maternal epigenetic pathways control parental contributions to Arabidopsis early embryogenesis. Cell. 145(5):707-19
  Autran D, Baroux C, Raissig MT, Lenormand T, Wittig M, Grob S, Steimer A, Barann M, Klostermeier UC, Leblanc O, Vielle-Calzada JP, Rosenstiel P, Grimanelli D, Grossniklaus U
  
• (2011). Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet. 44(2):187-92
  Paternoster L, ..., Australian Asthma Genetics Consortium (AAGC), ..., Genetics of Overweight Young Adults (GOYA) Consortium, ..., EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium
  
• (2011). Mutual antagonism of T cells causing psoriasis and atopic eczema. N Engl J Med. 365(3):231-8
  Eyerich S, Onken AT, Weidinger S, Franke A, Nasorri F, Pennino D, Grosber M, Pfab F, Schmidt-Weber CB, Mempel M, Hein R, Ring J, Cavani A, Eyerich K
  
• (2011). N Engl J Med. 364(12):1093-1103
  Vogelmeier C, Hederer B, Glaab T, Schmidt H, Rutten-van Mölken MP, Beeh KM, Rabe KF, Fabbri LM; POET-COPD Investigators
  
• (2011). Targeting interleukin-5 in refractory and relapsing Churg-Strauss syndrome. Ann Intern Med. 155(5):341-3
  Moosig F, Gross WL, Herrmann K, Bremer JP, Hellmich B
  
• (2011). Toward the blood-borne miRNome of human diseases. Nat Methods. 8(10):841-3
  Keller A, Leidinger P, Bauer A, Elsharawy A, Haas J, Backes C, Wendschlag A, Giese N, Tjaden C, Ott K, Werner J, Hackert T, Ruprecht K, Huwer H, Huebers J, Jacobs G, Rosenstiel P, Dommisch H, Schaefer A, Müller-Quernheim J, Wullich B, Keck B, Graf N, Reichrath J, Vogel B, Nebel A, Jager SU, Staehler P, Amarantos I, Boisguerin V, Staehler C, Beier M, Scheffler M, Büchler MW, Wischhusen J, Haeusler SF, Dietl J, Hofmann S, Lenhof HP, Schreiber S, Katus HA, Rottbauer W, Meder B, Hoheisel JD, Franke A, Meese E
  
• (2011). Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis. Gastroenterology. 141(1):227-36
  Lepage P, Häsler R, Spehlmann ME, Rehman A, Zvirbliene A, Begun A, Ott S, Kupcinskas L, Doré J, Raedler A, Schreiber S
  
• 2011). Human metabolic individuality in biomedical and pharmaceutical research. Nature. 477(7362):54-60
  Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, Wägele B, Altmaier E; CARDIoGRAM, Deloukas P, Erdmann J, Grundberg E, Hammond CJ, de Angelis MH, Kastenmüller G, Köttgen A, Kronenberg F, Mangino M, Meisinger C, Meitinger T, Mewes HW, Milburn MV, Prehn C, Raffler J, Ried JS, Römisch-Margl W, Samani NJ, Small KS, Wichmann HE, Zhai G, Illig T, Spector TD, Adamski J, Soranzo N, Gieger C
  
• 2011). Improvement of treatment-refractory atopic dermatitis by immunoadsorption: a pilot study. J Allergy Clin Immunol. 127(1):267-70, 270.e1-6
  Kasperkiewicz M, Schmidt E, Frambach Y, Rose C, Meier M, Nitschke M, Falk TM, Reich K, Ludwig RJ, Zillikens D
  
• (2012). Abatacept for Crohn's disease and ulcerative colitis. Gastroenterology. 143(1):62-69.e4
  Sandborn WJ, Colombel JF, Sands BE, Rutgeerts P, Targan SR, Panaccione R, Bressler B, Geboes K, Schreiber S, Aranda R, Gujrathi S, Luo A, Peng Y, Salter-Cid L, Hanauer SB
  
• (2012). ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature. 487(7408):477-81
  Hashimoto T, Perlot T, Rehman A, Trichereau J, Ishiguro H, Paolino M, Sigl V, Hanada T, Hanada R, Lipinski S, Wild B, Camargo SM, Singer D, Richter A, Kuba K, Fukamizu A, Schreiber S, Clevers H, Verrey F, Rosenstiel P, Penninger JM
  
• (2012). Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1. Nat Med. 18(9):1401-6
  Karsten CM, Pandey MK, Figge J, Kilchenstein R, Taylor PR, Rosas M, McDonald JU, Orr SJ, Berger M, Petzold D, Blanchard V, Winkler A, Hess C, Reid DM, Majoul IV, Strait RT, Harris NL, Köhl G, Wex E, Ludwig R, Zillikens D, Nimmerjahn F, Finkelman FD, Brown GD, Ehlers M, Köhl J
  
• (2012). Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 491(7422):119-24
  Jostins L, ..., International IBD Genetics Consortium (IIBDGC), ..., Cho JH
  
• (2012). Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet. 44(12):1341-8
  Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, Kang HM, Allen MH, McManus R, Novelli G, Samuelsson L, Schalkwijk J, Ståhle M, Burden AD, Smith CH, Cork MJ, Estivill X, Bowcock AM, Krueger GG, Weger W, Worthington J, Tazi-Ahnini R, Nestle FO, Hayday A, Hoffmann P, Winkelmann J, Wijmenga C, Langford C, Edkins S, Andrews R, Blackburn H, Strange A, Band G, Pearson RD, Vukcevic D, Spencer CC, Deloukas P, Mrowietz U, Schreiber S, Weidinger S, Koks S, Kingo K, Esko T, Metspalu A, Lim HW, Voorhees JJ, Weichenthal M, Wichmann HE, Chandran V, Rosen CF, Rahman P, Gladman DD, Griffiths CE, Reis A, Kere J; Collaborative Association Study of Psoriasis (CASP); Genetic Analysis of Psoriasis Consortium; Psoriasis Association Genetics Extension; Wellcome Trust Case Control Consortium 2, Nair RP, Franke A, Barker JN, Abecasis GR, Elder JT, Trembath RC
  
• (2012). The CD46- Jagged1 interaction is critical for human TH1 immunity. Nat Immunol. 13(12):1213-21
  Le Friec G, Sheppard D, Whiteman P, Karsten CM, Shamoun SA, Laing A, Bugeon L, Dallman MJ, Melchionna T, Chillakuri C, Smith RA, Drouet C, Couzi L, Fremeaux-Bacchi V, Köhl J, Waddington SN, McDonnell JM, Baker A, Handford PA, Lea SM, Kemper C
  
• (2012). Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med. 367(16):1519-28
  Sandborn WJ, Gasink C, Gao LL, Blank MA, Johanns J, Guzzo C, Sands BE, Hanauer SB, Targan S, Rutgeerts P, Ghosh S, de Villiers WJ, Panaccione R, Greenberg G, Schreiber S, Lichtiger S, Feagan BG; CERTIFI Study Group
  
• (2013). Dysfunctional nitric oxide signalling increases risk of myocardial infarction. Nature. 504(7480):432-6
  Erdmann J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, Kaiser FJ, Braunholz D, Medack A, Fischer M, Zimmermann ME, Tennstedt S, Graf E, Eck S, Aherrahrou Z, Nahrstaedt J, Willenborg C, Bruse P, Brænne I, Nöthen MM, Hofmann P, Braund PS, Mergia E, Reinhard W, Burgdorf C, Schreiber S, Balmforth AJ, Hall AS, Bertram L, Steinhagen-Thiessen E, Li SC, März W, Reilly M, Kathiresan S, McPherson R, Walter U; CARDIoGRAM, Ott J, Samani NJ, Strom TM, Meitinger T, Hengstenberg C, Schunkert H
  
• (2013). Genomewide mapping of gene-microbiota interactions in susceptibility to autoimmune skin blistering. Nat Commun. 4:2462
  Srinivas G, Möller S, Wang J, Künzel S, Zillikens D, Baines JF, Ibrahim SM
  
• (2013). High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. Nat Genet. 45(7):808-12
  Ellinghaus D, Baurecht H, Esparza-Gordillo J, Rodríguez E, Matanovic A, Marenholz I, Hübner N, Schaarschmidt H, Novak N, Michel S, Maintz L, Werfel T, Meyer-Hoffert U, Hotze M, Prokisch H, Heim K, Herder C, Hirota T, Tamari M, Kubo M, Takahashi A, Nakamura Y, Tsoi LC, Stuart P, Elder JT, Sun L, Zuo X, Yang S, Zhang X, Hoffmann P, Nöthen MM, Fölster-Holst R, Winkelmann J, Illig T, Boehm BO, Duerr RH, Büning C, Brand S, Glas J, McAleer MA, Fahy CM, Kabesch M, Brown S, McLean WH, Irvine AD, Schreiber S, Lee YA, Franke A, Weidinger S
  
• (2013). mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease. Gut. 62(3):376-86
  Derer S, Till A, Haesler R, Sina C, Grabe N, Jung S, Nikolaus S, Kuehbacher T, Groetzinger J, Rose-John S, Rosenstiel PC, Schreiber S
  
• (2013). NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J Clin Invest. 123(2):700-11
  Couturier-Maillard A, Secher T, Rehman A, Normand S, De Arcangelis A, Haesler R, Huot L, Grandjean T, Bressenot A, Delanoye-Crespin A, Gaillot O, Schreiber S, Lemoine Y, Ryffel B, Hot D, Nùñez G, Chen G, Rosenstiel P, Chamaillard M
  
• (2013). Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans. Nat Genet. 45(10):1176-82
  Comas I, Coscolla M, Luo T, Borrell S, Holt KE, Kato-Maeda M, Parkhill J, Malla B, Berg S, Thwaites G, Yeboah-Manu D, Bothamley G, Mei J, Wei L, Bentley S, Harris SR, Niemann S, Diel R, Aseffa A, Gao Q, Young D, Gagneux S
  
• (2013). Paneth cells as a site of origin for intestinal inflammation. Nature. 503(7475):272-6
  Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann- Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS
  
• (2013). T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies. J Clin Invest. 123(9):3788-96
  Hess C, Winkler A, Lorenz AK, Holecska V, Blanchard V, Eiglmeier S, Schoen AL, Bitterling J, Stoehr AD, Petzold D, Schommartz T, Mertes MM, Schoen CT, Tiburzy B, Herrmann A, Köhl J, Manz RA, Madaio MP, Berger M, Wardemann H, Ehlers M
  
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