EXC 306:  Inflammation at Interfaces

• Subject Area: Microbiology, Virology and Immunology
• Term: from 2007 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 49701054

• Final Report Year: 2019

Final Report Abstract

Chronic Inflammatory Barrier Diseases (CIBD) emerged as an increasing challenge due to their systemic biological effects on the organism and the complex interaction between genetic and environmental factors. In the Cluster’s first funding period (FP-1), the hypothetical disease model led the research process in a linear fashion from a few anticipated disease gene identifications to structure, evolutionary and functional annotation and exploration in patients. However, the unprecedented complexity and breadth of etiologic findings prompted a different approach in the second funding period (FP-2), in which our research strategy was developed further with Research Areas (RA) investigating in-depth key genetic, genomic and functional elements of inflammatory diseases while interacting with Cluster Laboratories (CL). The Cluster “Inflammation at Interfaces” combined the expertise and (inter-)national collaborations of a unique multidisciplinary team of >250 scientists from ten disciplines to drive the research of CIBD. A major achievement of the last decade is a profound change in the scientific culture and governance at all participating institutions/faculties, which has contributed to a significant increase in scientific productivity and visibility. Our local development is unique in its combination of disciplines and its strong concentration on clinical translation. This comprises a critical mass in interdisciplinary patient access across the entire field of CIBD, including re-organization of care for inflammation patients from different subspecialties in Comprehensive Centers for Inflammation Medicine (CCIM). This supports large cohort studies and therapeutic trials. The interdisciplinary research culture that resulted from this structural innovation has led to an outstanding series of high-impact findings. For example, Cluster scientists have led or contributed to many published international genetic meta-analyses and GWAS analyses for CIBD entities. Another developmental highlight of this Cluster was the development of an IL-6 trans-signaling inhibitor, which is currently being tested in a phase 2 trial for a CIBD. Our ongoing Cluster “Precision Medicine in Chronic Inflammation” (PMI) is based on the achievements of the previous Cluster and aims to describe an individual molecular efficacy signature for therapies in patients and will prompt individual choices of anti-inflammatory therapies in the future. The setup of a medical systems biology and a massive investment in IT were important pre-requirements and achievements of the FP-2. The ultimate goal of the new Cluster PMI is to define inflammatory barrier disease at early, not yet clinical, stages once it has reached a point-of-no-return and to develop rational interventions which intercept the further course.

Link to the final report

https://dx.doi.org/10.2314/KXP:1697278027

Publications

• (2007). A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet. 39(2):207-11
  Hampe, Jochen; Franke, Andre; Rosenstiel, Philip; Till, Andreas; Teuber, Markus; Huse, Klaus; Albrecht, Mario; Mayr, Gabriele; De La Vega, Francisco M; Briggs, Jason; Günther, Simone; Prescott, Natalie J; Onnie, Clive M; Häsler, Robert; Sipos, Bence; Fölsch, Ulrich R; Lengauer, Thomas; Platzer, Matthias; Mathew, Christopher G; ... & Schreiber, Stefan
  
• (2007). A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease. Nat Genet. 39(8):995-9
  Buch, Stephan; Schafmayer, Clemens; Völzke, Henry; Becker, Christian; Franke, Andre; von Eller-Eberstein, Huberta; Kluck, Christian; Bässmann, Ingelore; Brosch, Mario; Lammert, Frank; Miquel, Juan Francisco; Nervi, Flavio; Wittig, Michael; Rosskopf, Dieter; Timm, Birgit; Höll, Christine; Seeger, Marcus; ElSharawy, Abdou; Lu, Tim; ... & Hampe, Jochen
  
• (2007). Certolizumab pegol for the treatment of Crohn's disease. N Engl J Med. 357(3):228-38
  Sandborn, William J.; Feagan, Brian G.; Stoinov, Simeon; Honiball, Pieter J.; Rutgeerts, Paul; Mason, David; Bloomfield, Ralph & Schreiber, Stefan
  
• (2007). Genomewide association analysis of coronary artery disease. N Engl J Med. 357(5):443-53
  Samani, Nilesh J.; Erdmann, Jeanette; Hall, Alistair S.; Hengstenberg, Christian; Mangino, Massimo; Mayer, Bjoern; Dixon, Richard J.; Meitinger, Thomas; Braund, Peter; Wichmann, H.-Erich; Barrett, Jennifer H.; König, Inke R.; Stevens, Suzanne E.; Szymczak, Silke; Tregouet, David-Alexandre; Iles, Mark M.; Pahlke, Friedrich; Pollard, Helen; Lieb, Wolfgang; ... & Schunkert, Heribert
  
• (2007). LIMP-2 is a receptor for lysosomal mannose-6-phosphateindependent targeting of beta-glucocerebrosidase. Cell. 131(4):770-83
  Reczek, David; Schwake, Michael; Schröder, Jenny; Hughes, Heather; Blanz, Judith; Jin, Xiaoying; Brondyk, William; Van Patten, Scott; Edmunds, Tim & Saftig, Paul
  
• (2007). Maintenance therapy with certolizumab pegol for Crohn's disease. N Engl J Med. 357(3):239-50
  Schreiber, Stefan; Khaliq-Kareemi, Mani; Lawrance, Ian C.; Thomsen, Ole Østergaard; Hanauer, Stephen B.; McColm, Juliet; Bloomfield, Ralph & Sandborn, William J.
  
• (2007). Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature. 449(7162):564-9
  Lande, Roberto; Gregorio, Josh; Facchinetti, Valeria; Chatterjee, Bithi; Wang, Yi-Hong; Homey, Bernhard; Cao, Wei; Wang, Yui-Hsi; Su, Bing; Nestle, Frank O.; Zal, Tomasz; Mellman, Ira; Schröder, Jens-Michael; Liu, Yong-Jun & Gilliet, Michel
  
• (2008). Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science. 319(5863):624-7
  Asagiri, Masataka; Hirai, Toshitake; Kunigami, Toshihiro; Kamano, Shunya; Gober, Hans-Jürgen; Okamoto, Kazuo; Nishikawa, Keizo; Latz, Eicke; Golenbock, Douglas T.; Aoki, Kazuhiro; Ohya, Keiichi; Imai, Yuuki; Morishita, Yasuyuki; Miyazono, Kohei; Kato, Shigeaki; Saftig, Paul & Takayanagi, Hiroshi
  
• (2008). Emergence of extensive drug resistance during treatment for multidrugresistant tuberculosis. N Engl J Med. 359(22):2398-400
  Cox, Helen S.; Sibilia, Caterina; Feuerriegel, Silke; Kalon, Stobdan; Polonsky, Jonny; Khamraev, Atadjan K.; Rüsch-Gerdes, Sabine; Mills, Clair & Niemann, Stefan
  
• (2008). Genome-wide association analysis in sarcoidosis and Crohn's disease unravels a common susceptibility locus on 10p12.2. Gastroenterology. 135(4):1207-15
  Franke, Andre; Fischer, Annegret; Nothnagel, Michael; Becker, Christian; Grabe, Nils; Till, Andreas; Lu, Tim; Müller–Quernheim, Joachim; Wittig, Michael; Hermann, Alexander; Balschun, Tobias; Hofmann, Sylvia; Niemiec, Regina; Schulz, Sabrina; Hampe, Jochen; Nikolaus, Susanna; Nürnberg, Peter; Krawczak, Michael; Schürmann, Manfred; ... & Schreiber, Stefan
  
• (2008). Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. Nat Genet. 40(9):1103-6
  Hofmann, Sylvia; Franke, Andre; Fischer, Annegret; Jacobs, Gunnar; Nothnagel, Michael; Gaede, Karoline I; Schürmann, Manfred; Müller-Quernheim, Joachim; Krawczak, Michael; Rosenstiel, Philip & Schreiber, Stefan
  
• (2008). Regulatory networks define phenotypic classes of human stem cell lines. Nature. 455(7211):401-5
  Müller, Franz-Josef; Laurent, Louise C.; Kostka, Dennis; Ulitsky, Igor; Williams, Roy; Lu, Christina; Park, In-Hyun; Rao, Mahendra S.; Shamir, Ron; Schwartz, Philip H.; Schmidt, Nils O. & Loring, Jeanne F.
  
• (2008). Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nat Genet. 40(6):713-5
  Franke, Andre; Balschun, Tobias; Karlsen, Tom H; Hedderich, Jürgen; May, Sandra; Lu, Tim; Schuldt, Dörthe; Nikolaus, Susanna; Rosenstiel, Philip; Krawczak, Michael & Schreiber, Stefan
  
• (2008). Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet. 40(11):1319-23
  Franke, Andre; Balschun, Tobias; Karlsen, Tom H; Sventoraityte, Jurgita; Nikolaus, Susanna; Mayr, Gabriele; Domingues, Francisco S; Albrecht, Mario; Nothnagel, Michael; Ellinghaus, David; Sina, Christian; Onnie, Clive M; Weersma, Rinse K; Stokkers, Pieter C F; Wijmenga, Cisca; Gazouli, Maria; Strachan, David; McArdle, Wendy L; Vermeire, Séverine; ... & Schreiber, Stefan
  
• (2008). XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 134(5):743-56
  Kaser, Arthur; Lee, Ann-Hwee; Franke, Andre; Glickman, Jonathan N.; Zeissig, Sebastian; Tilg, Herbert; Nieuwenhuis, Edward E.S.; Higgins, Darren E.; Schreiber, Stefan; Glimcher, Laurie H. & Blumberg, Richard S.
  
• (2009). A common variant on chromosome 11q13 is associated with atopic dermatitis. Nat Genet. 41(5):596-601
  Esparza-Gordillo, Jorge; Weidinger, Stephan; Fölster-Holst, Regina; Bauerfeind, Anja; Ruschendorf, Franz; Patone, Giannino; Rohde, Klaus; Marenholz, Ingo; Schulz, Florian; Kerscher, Tamara; Hubner, Norbert; Wahn, Ulrich; Schreiber, Stefan; Franke, Andre; Vogler, Rainer; Heath, Simon; Baurecht, Hansjörg; Novak, Natalija; Rodriguez, Elke; ... & Ruether, Andreas
  
• (2009). New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet. 41(3):280-2
  Erdmann, Jeanette; Großhennig, Anika; Braund, Peter S; König, Inke R; Hengstenberg, Christian; Hall, Alistair S; Linsel-Nitschke, Patrick; Kathiresan, Sekar; Wright, Ben; Trégouët, David-Alexandre; Cambien, Francois; Bruse, Petra; Aherrahrou, Zouhair; Wagner, Arnika K; Stark, Klaus; Schwartz, Stephen M; Salomaa, Veikko; Elosua, Roberto; Melander, Olle; ... & Schunkert, Heribert
  
• (2009). Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature. 460(7259):1159-63
  Yazdanpanah, Benjamin; Wiegmann, Katja; Tchikov, Vladimir; Krut, Oleg; Pongratz, Carola; Schramm, Michael; Kleinridders, Andre; Wunderlich, Thomas; Kashkar, Hamid; Utermöhlen, Olaf; Brüning, Jens C.; Schütze, Stefan & Krönke, Martin
  
• (2010). A phylogenetically based transcriptome age index mirrors ontogenetic divergence patterns. Nature. 468(7325):815-8
  Domazet-Lošo, Tomislav & Tautz, Diethard
  
• (2010). Autosomal-dominant striatal degeneration is caused by a mutation in the phosphodiesterase 8B gene. Am J Hum Genet. 86(1):83-7
  Appenzeller, Silke; Schirmacher, Anja; Halfter, Hartmut; Bäumer, Sebastian; Pendziwiat, Manuela; Timmerman, Vincent; De Jonghe, Peter; Fekete, Klára; Stögbauer, Florian; Lüdemann, Peter; Hund, Margret; Quabius, Elgar Susanne; Ringelstein, E. Bernd & Kuhlenbäumer, Gregor
  
• (2010). Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med. 207(8):1617-24
  Chalaris, Athena; Adam, Nina; Sina, Christian; Rosenstiel, Philip; Lehmann-Koch, Judith; Schirmacher, Peter; Hartmann, Dieter; Cichy, Joanna; Gavrilova, Olga; Schreiber, Stefan; Jostock, Thomas; Matthews, Vance; Häsler, Robert; Becker, Christoph; Neurath, Markus F.; Reiß, Karina; Saftig, Paul; Scheller, Jürgen & Rose-John, Stefan
  
• (2010). Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). Nat Genet. 42(4):292-4
  Franke, Andre; Balschun, Tobias; Sina, Christian; Ellinghaus, David; Häsler, Robert; Mayr, Gabriele; Albrecht, Mario; Wittig, Michael; Buchert, Eva; Nikolaus, Susanna; Gieger, Christian; Wichmann, H Erich; Sventoraityte, Jurgita; Kupcinskas, Limas; Onnie, Clive M; Gazouli, Maria; Anagnou, Nicholas P; Strachan, David; McArdle, Wendy L; ... & Schreiber, Stefan
  
• (2010). Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat Genet. 42(11):991-5
  Ellinghaus, Eva; Ellinghaus, David; Stuart, Philip E; Nair, Rajan P; Debrus, Sophie; Raelson, John V; Belouchi, Majid; Fournier, Hélène; Reinhard, Claudia; Ding, Jun; Li, Yun; Tejasvi, Trilokraj; Gudjonsson, Johann; Stoll, Stefan W; Voorhees, John J; Lambert, Sylviane; Weidinger, Stephan; Eberlein, Bernadette; Kunz, Manfred; ... & Franke, Andre
  
• (2010). Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet. 42(12):1118-25
  Franke, Andre; McGovern, Dermot P B; Barrett, Jeffrey C; Wang, Kai; Radford-Smith, Graham L; Ahmad, Tariq; Lees, Charlie W; Balschun, Tobias; Lee, James; Roberts, Rebecca; Anderson, Carl A; Bis, Joshua C; Bumpstead, Suzanne; Ellinghaus, David; Festen, Eleonora M; Georges, Michel; Green, Todd; Haritunians, Talin; Jostins, Luke; ... & Parkes, Miles
  
• (2010). In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides. Proc Natl Acad Sci USA. 107(42):18067-72
  Fraune, Sebastian; Augustin, René; Anton-Erxleben, Friederike; Wittlieb, Jörg; Gelhaus, Christoph; Klimovich, Vladimir B.; Samoilovich, Marina P. & Bosch, Thomas C. G.
  
• (2011). Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nat Genet. 43(1):17-9
  Melum, Espen; Franke, Andre; Schramm, Christoph; Weismüller, Tobias J.; Gotthardt, Daniel Nils; Offner, Felix A.; Juran, Brian D.; Laerdahl, Jon K.; Labi, Verena; Björnsson, Einar; Weersma, Rinse K.; Henckaerts, Liesbet; Teufel, Andreas; Rust, Christian;
  
• (2011). Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype. Proc Natl Acad Sci USA. 108(47):19030-5
  Rausch, Philipp; Rehman, Ateequr; Künzel, Sven; Häsler, Robert; Ott, Stephan J.; Schreiber, Stefan; Rosenstiel, Philip; Franke, Andre & Baines, John F.
  
• (2011). Heat-shock protein 90 inhibition in autoimmunity to type VII collagen: evidence that nonmalignant plasma cells are not therapeutic targets. Blood. 117(23):6135-42
  Kasperkiewicz, Michael; Müller, Ralf; Manz, Rudolf; Magens, Moritz; Hammers, Christoph M.; Somlai, Csaba; Westermann, Jürgen; Schmidt, Enno; Zillikens, Detlef; Ludwig, Ralf J. & Orosz, Antal
  
• (2011). Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 43(4):333-8
  Schunkert, Heribert; König, Inke R; Kathiresan, Sekar; Reilly, Muredach P; Assimes, Themistocles L; Holm, Hilma; Preuss, Michael; Stewart, Alexandre F R; Barbalic, Maja; Gieger, Christian; Absher, Devin; Aherrahrou, Zouhair; Allayee, Hooman; Altshuler, David; Anand, Sonia S; Andersen, Karl; Anderson, Jeffrey L; Ardissino, Diego; Ball, Stephen G; ... & Erdmann, Jeanette
  
• (2011). Maternal epigenetic pathways control parental contributions to Arabidopsis early embryogenesis. Cell. 145(5):707-19
  Autran, Daphné; Baroux, Célia; Raissig, Michael T.; Lenormand, Thomas; Wittig, Michael; Grob, Stefan; Steimer, Andrea; Barann, Matthias; Klostermeier, Ulrich C.; Leblanc, Olivier; Vielle-Calzada, Jean-Philippe; Rosenstiel, Phillip; Grimanelli, Daniel & Grossniklaus, Ueli
  
• (2011). Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet. 44(2):187-92
  Paternoster, Lavinia; Standl, Marie; Chen, Chih-Mei; Ramasamy, Adaikalavan; Bønnelykke, Klaus; Duijts, Liesbeth; Ferreira, Manuel A.; Alves, Alexessander Couto; Thyssen, Jacob P.; Albrecht, Eva; Baurecht, Hansjörg; Feenstra, Bjarke; Sleiman, Patrick M. A.
  
• (2011). Mutual antagonism of T cells causing psoriasis and atopic eczema. N Engl J Med. 365(3):231-8
  Eyerich, Stefanie; Onken, Anna T.; Weidinger, Stephan; Franke, Andre; Nasorri, Francesca; Pennino, Davide; Grosber, Martine; Pfab, Florian; Schmidt-Weber, Carsten B.; Mempel, Martin; Hein, Ruediger; Ring, Johannes; Cavani, Andrea & Eyerich, Kilian
  
• (2011). N Engl J Med. 364(12):1093-1103
  Vogelmeier, Claus; Hederer, Bettina; Glaab, Thomas; Schmidt, Hendrik; Rutten-van Mölken, Maureen P.M.H.; Beeh, Kai M.; Rabe, Klaus F. & Fabbri, Leonardo M.
  
• (2011). Targeting interleukin-5 in refractory and relapsing Churg-Strauss syndrome. Ann Intern Med. 155(5):341-3
  Moosig, Frank; Gross, Wolfgang Ludwig; Herrmann, Kristina; Bremer, Jan Phillip & Hellmich, Bernhard
  
• (2011). Toward the blood-borne miRNome of human diseases. Nat Methods. 8(10):841-3
  Keller, Andreas; Leidinger, Petra; Bauer, Andrea; ElSharawy, Abdou; Haas, Jan; Backes, Christina; Wendschlag, Anke; Giese, Nathalia; Tjaden, Christine; Ott, Katja; Werner, Jens; Hackert, Thilo; Ruprecht, Klemens; Huwer, Hanno; Huebers, Junko; Jacobs, Gunnar; Rosenstiel, Philip; Dommisch, Henrik; Schaefer, Arne; ... & Meese, Eckart
  
• (2011). Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis. Gastroenterology. 141(1):227-36
  Lepage, Patricia; Häsler, Robert; Spehlmann, Martina E.; Rehman, Ateequr; Zvirbliene, Aida; Begun, Alexander; Ott, Stephan; Kupcinskas, Limas; Doré, Joël; Raedler, Andreas & Schreiber, Stefan
  
• 2011). Human metabolic individuality in biomedical and pharmaceutical research. Nature. 477(7362):54-60
  Suhre, Karsten; Shin, So-Youn; Petersen, Ann-Kristin; Mohney, Robert P.; Meredith, David; Wägele, Brigitte; Altmaier, Elisabeth; Deloukas, Panos; Erdmann, Jeanette; Grundberg, Elin; Hammond, Christopher J.; de Angelis, Martin Hrabé; Kastenmüller, Gabi; Köttgen, Anna; Kronenberg, Florian; Mangino, Massimo; Meisinger, Christa; Meitinger, Thomas; Mewes, Hans-Werner; ... & Gieger, Christian
  
• 2011). Improvement of treatment-refractory atopic dermatitis by immunoadsorption: a pilot study. J Allergy Clin Immunol. 127(1):267-70, 270.e1-6
  Kasperkiewicz, Michael; Schmidt, Enno; Frambach, Yvonne; Rose, Christian; Meier, Markus; Nitschke, Martin; Falk, Thomas M.; Reich, Kristian; Ludwig, Ralf J. & Zillikens, Detlef
  
• (2012). Abatacept for Crohn's disease and ulcerative colitis. Gastroenterology. 143(1):62-69.e4
  Sandborn, William J.; Colombel, Jean–Frederic; Sands, Bruce E.; Rutgeerts, Paul; Targan, Stephan R.; Panaccione, Remo; Bressler, Brian; Geboes, Karl; Schreiber, Stefan; Aranda, Richard; Gujrathi, Sheila; Luo, Allison; Peng, Yun; Salter–Cid, Luisa & Hanauer, Stephen B.
  
• (2012). ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature. 487(7408):477-81
  Hashimoto, Tatsuo; Perlot, Thomas; Rehman, Ateequr; Trichereau, Jean; Ishiguro, Hiroaki; Paolino, Magdalena; Sigl, Verena; Hanada, Toshikatsu; Hanada, Reiko; Lipinski, Simone; Wild, Birgit; Camargo, Simone M. R.; Singer, Dustin; Richter, Andreas; Kuba, Keiji; Fukamizu, Akiyoshi; Schreiber, Stefan; Clevers, Hans; Verrey, Francois; ... & Penninger, Josef M.
  
• (2012). Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1. Nat Med. 18(9):1401-6
  Karsten, Christian M; Pandey, Manoj K; Figge, Julia; Kilchenstein, Regina; Taylor, Philip R; Rosas, Marcela; McDonald, Jacqueline U; Orr, Selinda J; Berger, Markus; Petzold, Dominique; Blanchard, Veroniqué; Winkler, André; Hess, Constanze; Reid, Delyth M; Majoul, Irina V; Strait, Richard T; Harris, Nathaniel L; Köhl, Gabriele; Wex, Eva; ... & Köhl, Jörg
  
• (2012). Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 491(7422):119-24
  Jostins, Luke; Ripke, Stephan; Weersma, Rinse K.; Duerr, Richard H.; Mcgovern, Dermot P.; Hui, Ken Y.; Lee, James C.; Philip Schumm, L.; Sharma, Yashoda; Anderson, Carl A.; Essers, Jonah; Mitrovic, Mitja; Ning, Kaida; Cleynen, Isabelle; Theatre, Emilie; S
  
• (2012). Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet. 44(12):1341-8
  Tsoi, Lam C.; Spain, Sarah L.; Knight, Jo; Ellinghaus, Eva; Stuart, Philip E.; Capon, Francesca; Ding, Jun; Li, Yanming; Tejasvi, Trilokraj; Gudjonsson, Johann E.; Kang, Hyun M.; Allen, Michael H.; Mcmanus, Ross; Novelli, Giuseppe; Samuelsson, Lena; Schal
  
• (2012). The CD46- Jagged1 interaction is critical for human TH1 immunity. Nat Immunol. 13(12):1213-21
  Le Friec, Gaëlle; Sheppard, Devon; Whiteman, Pat; Karsten, Christian M; Shamoun, Salley Al-Tilib; Laing, Adam; Bugeon, Laurence; Dallman, Margaret J; Melchionna, Teresa; Chillakuri, Chandramouli; Smith, Richard A; Drouet, Christian; Couzi, Lionel; Fremeaux-Bacchi, Veronique; Köhl, Jörg; Waddington, Simon N; McDonnell, James M; Baker, Alastair; Handford, Penny A; ... & Kemper, Claudia
  
• (2012). Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med. 367(16):1519-28
  Sandborn, William J.; Gasink, Christopher; Gao, Long-Long; Blank, Marion A.; Johanns, Jewel; Guzzo, Cynthia; Sands, Bruce E.; Hanauer, Stephen B.; Targan, Stephan; Rutgeerts, Paul; Ghosh, Subrata; de Villiers, Willem J.S.; Panaccione, Remo; Greenberg, Gordon; Schreiber, Stefan; Lichtiger, Simon & Feagan, Brian G.
  
• (2013). mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease. Gut. 62(3):376-86
  Derer, Stefanie; Till, Andreas; Haesler, Robert; Sina, Christian; Grabe, Nils; Jung, Sascha; Nikolaus, Susanna; Kuehbacher, Tanja; Groetzinger, Joachim; Rose-John, Stefan; Rosenstiel, Philip C & Schreiber, Stefan
  
• (2013). Dysfunctional nitric oxide signalling increases risk of myocardial infarction. Nature. 504(7480):432-6
  Erdmann, Jeanette; Stark, Klaus; Esslinger, Ulrike B.; Rumpf, Philipp Moritz; Koesling, Doris; de Wit, Cor; Kaiser, Frank J.; Braunholz, Diana; Medack, Anja; Fischer, Marcus; Zimmermann, Martina E.; Tennstedt, Stephanie; Graf, Elisabeth; Eck, Sebastian; Aherrahrou, Zouhair; Nahrstaedt, Janja; Willenborg, Christina; Bruse, Petra; Brænne, Ingrid; ... & Schunkert, Heribert
  
• (2013). Genomewide mapping of gene-microbiota interactions in susceptibility to autoimmune skin blistering. Nat Commun. 4:2462
  Srinivas, Girish; Möller, Steffen; Wang, Jun; Künzel, Sven; Zillikens, Detlef; Baines, John F. & Ibrahim, Saleh M.
  
• (2013). High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. Nat Genet. 45(7):808-12
  Ellinghaus, David; Baurecht, Hansjörg; Esparza-Gordillo, Jorge; Rodríguez, Elke; Matanovic, Anja; Marenholz, Ingo; Hübner, Norbert; Schaarschmidt, Heidi; Novak, Natalija; Michel, Sven; Maintz, Laura; Werfel, Thomas; Meyer-Hoffert, Ulf; Hotze, Melanie; Prokisch, Holger; Heim, Katharina; Herder, Christian; Hirota, Tomomitsu; Tamari, Mayumi; ... & Weidinger, Stephan
  
• (2013). NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J Clin Invest. 123(2):700-11
  Couturier-Maillard, Aurélie; Secher, Thomas; Rehman, Ateequr; Normand, Sylvain; De Arcangelis, Adèle; Haesler, Robert; Huot, Ludovic; Grandjean, Teddy; Bressenot, Aude; Delanoye-Crespin, Anne; Gaillot, Olivier; Schreiber, Stefan; Lemoine, Yves; Ryffel, Bernhard; Hot, David; Nùñez, Gabriel; Chen, Grace; Rosenstiel, Philip & Chamaillard, Mathias
  
• (2013). Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans. Nat Genet. 45(10):1176-82
  Comas, Iñaki; Coscolla, Mireia; Luo, Tao; Borrell, Sonia; Holt, Kathryn E; Kato-Maeda, Midori; Parkhill, Julian; Malla, Bijaya; Berg, Stefan; Thwaites, Guy; Yeboah-Manu, Dorothy; Bothamley, Graham; Mei, Jian; Wei, Lanhai; Bentley, Stephen; Harris, Simon R; Niemann, Stefan; Diel, Roland; Aseffa, Abraham; ... & Gagneux, Sebastien
  
• (2013). Paneth cells as a site of origin for intestinal inflammation. Nature. 503(7475):272-6
  Adolph, Timon E.; Tomczak, Michal F.; Niederreiter, Lukas; Ko, Hyun-Jeong; Böck, Janne; Martinez-Naves, Eduardo; Glickman, Jonathan N.; Tschurtschenthaler, Markus; Hartwig, John; Hosomi, Shuhei; Flak, Magdalena B.; Cusick, Jennifer L.; Kohno, Kenji; Iwawaki, Takao; Billmann-Born, Susanne; Raine, Tim; Bharti, Richa; Lucius, Ralph; Kweon, Mi-Na; ... & Blumberg, Richard S.
  
• (2013). T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies. J Clin Invest. 123(9):3788-96
  Hess, Constanze; Winkler, André; Lorenz, Alexandra K.; Holecska, Vivien; Blanchard, Véronique; Eiglmeier, Susanne; Schoen, Anna-Lena; Bitterling, Josephine; Stoehr, Alexander D.; Petzold, Dominique; Schommartz, Tim; Mertes, Maria M.M.; Schoen, Carolin T.; Tiburzy, Ben; Herrmann, Anne; Köhl, Jörg; Manz, Rudolf A.; Madaio, Michael P.; Berger, Markus; ... & Ehlers, Marc
  
• (2013). Transcriptome and genome sequencing uncovers functional variation in humans. Nature. 501(7468):506-11
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