EXC 306:  Inflammation at Interfaces

• Subject Area: Microbiology, Virology and Immunology
• Term: from 2007 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 49701054

• Final Report Year: 2019

Final Report Abstract

Chronic Inflammatory Barrier Diseases (CIBD) emerged as an increasing challenge due to their systemic biological effects on the organism and the complex interaction between genetic and environmental factors. In the Cluster’s first funding period (FP-1), the hypothetical disease model led the research process in a linear fashion from a few anticipated disease gene identifications to structure, evolutionary and functional annotation and exploration in patients. However, the unprecedented complexity and breadth of etiologic findings prompted a different approach in the second funding period (FP-2), in which our research strategy was developed further with Research Areas (RA) investigating in-depth key genetic, genomic and functional elements of inflammatory diseases while interacting with Cluster Laboratories (CL). The Cluster “Inflammation at Interfaces” combined the expertise and (inter-)national collaborations of a unique multidisciplinary team of >250 scientists from ten disciplines to drive the research of CIBD. A major achievement of the last decade is a profound change in the scientific culture and governance at all participating institutions/faculties, which has contributed to a significant increase in scientific productivity and visibility. Our local development is unique in its combination of disciplines and its strong concentration on clinical translation. This comprises a critical mass in interdisciplinary patient access across the entire field of CIBD, including re-organization of care for inflammation patients from different subspecialties in Comprehensive Centers for Inflammation Medicine (CCIM). This supports large cohort studies and therapeutic trials. The interdisciplinary research culture that resulted from this structural innovation has led to an outstanding series of high-impact findings. For example, Cluster scientists have led or contributed to many published international genetic meta-analyses and GWAS analyses for CIBD entities. Another developmental highlight of this Cluster was the development of an IL-6 trans-signaling inhibitor, which is currently being tested in a phase 2 trial for a CIBD. Our ongoing Cluster “Precision Medicine in Chronic Inflammation” (PMI) is based on the achievements of the previous Cluster and aims to describe an individual molecular efficacy signature for therapies in patients and will prompt individual choices of anti-inflammatory therapies in the future. The setup of a medical systems biology and a massive investment in IT were important pre-requirements and achievements of the FP-2. The ultimate goal of the new Cluster PMI is to define inflammatory barrier disease at early, not yet clinical, stages once it has reached a point-of-no-return and to develop rational interventions which intercept the further course.

Link to the final report

https://dx.doi.org/10.2314/KXP:1697278027

Publications

• (2007). A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease. Nat Genet. 39(8):995-9
  Buch S, Schafmayer C, Völzke H, Becker C, Franke A, von Eller-Eberstein H, Kluck C, Bässmann I, Brosch M, Lammert F, Miquel JF, Nervi F, Wittig M, Rosskopf D, Timm B, Höll C, Seeger M, ElSharawy A, Lu T, Egberts J, Fändrich F, Fölsch UR, Krawczak M, Schreiber S, Nürnberg P, Tepel J, Hampe J
  (See online at https://doi.org/10.1038/ng2101)
• (2007). A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet. 39(2):207-11
  Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G, De La Vega FM, Briggs J, Günther S, Prescott NJ, Onnie CM, Häsler R, Sipos B, Fölsch UR, Lengauer T, Platzer M, Mathew CG, Krawczak M, Schreiber S
  (See online at https://doi.org/10.1038/ng1954)
• (2007). Certolizumab pegol for the treatment of Crohn's disease. N Engl J Med. 357(3):228-38
  Sandborn WJ, Feagan BG, Stoinov S, Honiball PJ, Rutgeerts P, Mason D, Bloomfield R, Schreiber S; PRECISE 1 Study Investigators
  (See online at https://doi.org/10.1056/NEJMoa067594)
• (2007). Genomewide association analysis of coronary artery disease. N Engl J Med. 357(5):443-53
  Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, König IR, Stevens SE, Szymczak S, Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien F, Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas P, Tobin MD, Ziegler A, Thompson JR, Schunkert H; WTCCC and the Cardiogenics Consortium
  (See online at https://doi.org/10.1056/NEJMoa072366)
• (2007). LIMP-2 is a receptor for lysosomal mannose-6-phosphateindependent targeting of beta-glucocerebrosidase. Cell. 131(4):770-83
  Reczek D, Schwake M, Schröder J, Hughes H, Blanz J, Jin X, Brondyk W, Van Patten S, Edmunds T, Saftig P
  (See online at https://doi.org/10.1016/j.cell.2007.10.018)
• (2007). Maintenance therapy with certolizumab pegol for Crohn's disease. N Engl J Med. 357(3):239-50
  Schreiber S, Khaliq-Kareemi M, Lawrance IC, Thomsen OØ, Hanauer SB, McColm J, Bloomfield R, Sandborn WJ; PRECISE 2 Study Investigators
  (See online at https://doi.org/10.1056/NEJMoa062897)
• (2007). Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature. 449(7162):564-9
  Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, Cao W, Wang YH, Su B, Nestle FO, Zal T, Mellman I, Schröder JM, Liu YJ, Gilliet M
  (See online at https://doi.org/10.1038/nature06116)
• (2008). Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science. 319(5863):624-7
  Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H
  (See online at https://doi.org/10.1126/science.1150110)
• (2008). Emergence of extensive drug resistance during treatment for multidrugresistant tuberculosis. N Engl J Med. 359(22):2398-400
  Cox HS, Sibilia K, Feuerriegel S, Kalon S, Polonsky J, Khamraev AK, Rüsch-Gerdes S, Mills C, Niemann S
  (See online at https://doi.org/10.1056/NEJMc0805644)
• (2008). Genome-wide association analysis in sarcoidosis and Crohn's disease unravels a common susceptibility locus on 10p12.2. Gastroenterology. 135(4):1207-15
  Franke A, Fischer A, Nothnagel M, Becker C, Grabe N, Till A, Lu T, Müller-Quernheim J, Wittig M, Hermann A, Balschun T, Hofmann S, Niemiec R, Schulz S, Hampe J, Nikolaus S, Nürnberg P, Krawczak M, Schürmann M, Rosenstiel P, Nebel A, Schreiber S
  (See online at https://doi.org/10.1053/j.gastro.2008.07.017)
• (2008). Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. Nat Genet. 40(9):1103-6
  Hofmann S, Franke A, Fischer A, Jacobs G, Nothnagel M, Gaede KI, Schürmann M, Müller- Quernheim J, Krawczak M, Rosenstiel P, Schreiber S
  (See online at https://doi.org/10.1038/ng.198)
• (2008). Regulatory networks define phenotypic classes of human stem cell lines. Nature. 455(7211):401-5
  Müller FJ, Laurent LC, Kostka D, Ulitsky I, Williams R, Lu C, Park IH, Rao MS, Shamir R, Schwartz PH, Schmidt NO, Loring JF
  (See online at https://doi.org/10.1038/nature07213)
• (2008). Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nat Genet. 40(6):713-5
  Franke A, Balschun T, Karlsen TH, Hedderich J, May S, Lu T, Schuldt D, Nikolaus S, Rosenstiel P, Krawczak M, Schreiber S
  (See online at https://doi.org/10.1038/ng.148)
• (2008). Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet. 40(11):1319-23
  Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, Sina C, Onnie CM, Weersma RK, Stokkers PC, Wijmenga C, Gazouli M, Strachan D, McArdle WL, Vermeire S, Rutgeerts P, Rosenstiel P, Krawczak M, Vatn MH; IBSEN study group, Mathew CG, Schreiber S
  (See online at https://doi.org/10.1038/ng.221)
• (2008). XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 134(5):743-56
  Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH, Blumberg RS
  (See online at https://doi.org/10.1016/j.cell.2008.07.021)
• (2009). A common variant on chromosome 11q13 is associated with atopic dermatitis. Nat Genet. 41(5):596-601
  Esparza-Gordillo J, Weidinger S, Fölster-Holst R, Bauerfeind A, Ruschendorf F, Patone G, Rohde K, Marenholz I, Schulz F, Kerscher T, Hubner N, Wahn U, Schreiber S, Franke A, Vogler R, Heath S, Baurecht H, Novak N, Rodriguez E, Illig T, Lee-Kirsch MA, Ciechanowicz A, Kurek M, Piskackova T, Macek M, Lee YA, Ruether A
  (See online at https://doi.org/10.1038/ng.347)
• (2009). New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet. 41(3):280-2
  Erdmann J, ..., et al.; Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group; Myocardial Infarction Genetics Consortium; Wellcome Trust Case Control Consortium; Cardiogenics Consortium
  (See online at https://doi.org/10.1038/ng.307)
• (2009). Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature. 460(7259):1159-63
  Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pongratz C, Schramm M, Kleinridders A, Wunderlich T, Kashkar H, Utermöhlen O, Brüning JC, Schütze S, Krönke M
  (See online at https://doi.org/10.1038/nature08206)
• (2010). A phylogenetically based transcriptome age index mirrors ontogenetic divergence patterns. Nature. 468(7325):815-8
  Domazet-Lošo T, Tautz D
  (See online at https://doi.org/10.1038/nature09632)
• (2010). Autosomal-dominant striatal degeneration is caused by a mutation in the phosphodiesterase 8B gene. Am J Hum Genet. 86(1):83-7
  Appenzeller S, Schirmacher A, Halfter H, Bäumer S, Pendziwiat M, Timmerman V, De Jonghe P, Fekete K, Stögbauer F, Lüdemann P, Hund M, Quabius ES, Ringelstein EB, Kuhlenbäumer G
  (See online at https://doi.org/10.1016/j.ajhg.2009.12.003)
• (2010). Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med. 207(8):1617-24
  Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S
  (See online at https://doi.org/10.1084/jem.20092366)
• (2010). Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). Nat Genet. 42(4):292-4
  Franke A, Balschun T, Sina C, Ellinghaus D, Häsler R, Mayr G, Albrecht M, Wittig M, Buchert E, Nikolaus S, Gieger C, Wichmann HE, Sventoraityte J, Kupcinskas L, Onnie CM, Gazouli M, Anagnou NP, Strachan D, McArdle WL, Mathew CG, Rutgeerts P, Vermeire S, Vatn MH; IBSEN study group, Krawczak M, Rosenstiel P, Karlsen TH, Schreiber S
  (See online at https://doi.org/10.1038/ng.553)
• (2010). Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat Genet. 42(11):991-5
  Ellinghaus E, Ellinghaus D, Stuart PE, Nair RP, Debrus S, Raelson JV, Belouchi M, Fournier H, Reinhard C, Ding J, Li Y, Tejasvi T, Gudjonsson J, Stoll SW, Voorhees JJ, Lambert S, Weidinger S, Eberlein B, Kunz M, Rahman P, Gladman DD, Gieger C, Wichmann HE, Karlsen TH, Mayr G, Albrecht M, Kabelitz D, Mrowietz U, Abecasis GR, Elder JT, Schreiber S, Weichenthal M, Franke A
  (See online at https://doi.org/10.1038/ng.689)
• (2010). Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet. 42(12):1118-25
  Franke A, ..., Parkes M
  (See online at https://doi.org/10.1038/ng.717)
• (2010). In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides. Proc Natl Acad Sci USA. 107(42):18067-72
  Fraune S, Augustin R, Anton-Erxleben F, Wittlieb J, Gelhaus C, Klimovich VB, Samoilovich MP, Bosch TC
  (See online at https://doi.org/10.1073/pnas.1008573107)
• (2011). Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype. Proc Natl Acad Sci USA. 108(47):19030-5
  Rausch P, Rehman A, Künzel S, Häsler R, Ott SJ, Schreiber S, Rosenstiel P, Franke A, Baines JF
  (See online at https://doi.org/10.1073/pnas.1106408108)
• (2011). Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nat Genet. 43(1):17-9
  Melum E, Franke A, Schramm C, Weismüller TJ, Gotthardt DN, Offner FA, Juran BD, Laerdahl JK, Labi V, Björnsson E, Weersma RK, Henckaerts L, Teufel A, Rust C, Ellinghaus E, Balschun T, Boberg KM, Ellinghaus D, Bergquist A, Sauer P, Ryu E, Hov JR, Wedemeyer J, Lindkvist B, Wittig M, Porte RJ, Holm K, Gieger C, Wichmann HE, Stokkers P, Ponsioen CY, Runz H, Stiehl A, Wijmenga C, Sterneck M, Vermeire S, Beuers U, Villunger A, Schrumpf E, Lazaridis KN, Manns MP, Schreiber S, Karlsen TH
  (See online at https://doi.org/10.1038/ng.728)
• (2011). Heat-shock protein 90 inhibition in autoimmunity to type VII collagen: evidence that nonmalignant plasma cells are not therapeutic targets. Blood. 117(23):6135-42
  Kasperkiewicz M, Müller R, Manz R, Magens M, Hammers CM, Somlai C, Westermann J, Schmidt E, Zillikens D, Ludwig RJ, Orosz A
  (See online at https://doi.org/10.1182/blood-2010-10-314609)
• (2011). Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 43(4):333-8
  Schunkert H, ..., CARDIoGRAM Consortium, Samani NJ
  (See online at https://doi.org/10.1038/ng.784)
• (2011). Maternal epigenetic pathways control parental contributions to Arabidopsis early embryogenesis. Cell. 145(5):707-19
  Autran D, Baroux C, Raissig MT, Lenormand T, Wittig M, Grob S, Steimer A, Barann M, Klostermeier UC, Leblanc O, Vielle-Calzada JP, Rosenstiel P, Grimanelli D, Grossniklaus U
  (See online at https://doi.org/10.1016/j.cell.2011.04.014)
• (2011). Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet. 44(2):187-92
  Paternoster L, ..., Australian Asthma Genetics Consortium (AAGC), ..., Genetics of Overweight Young Adults (GOYA) Consortium, ..., EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium
  (See online at https://doi.org/10.1038/ng.1017)
• (2011). Mutual antagonism of T cells causing psoriasis and atopic eczema. N Engl J Med. 365(3):231-8
  Eyerich S, Onken AT, Weidinger S, Franke A, Nasorri F, Pennino D, Grosber M, Pfab F, Schmidt-Weber CB, Mempel M, Hein R, Ring J, Cavani A, Eyerich K
  (See online at https://doi.org/10.1056/NEJMoa1104200)
• (2011). N Engl J Med. 364(12):1093-1103
  Vogelmeier C, Hederer B, Glaab T, Schmidt H, Rutten-van Mölken MP, Beeh KM, Rabe KF, Fabbri LM; POET-COPD Investigators
  (See online at https://doi.org/10.1056/NEJMoa1008378)
• (2011). Targeting interleukin-5 in refractory and relapsing Churg-Strauss syndrome. Ann Intern Med. 155(5):341-3
  Moosig F, Gross WL, Herrmann K, Bremer JP, Hellmich B
  (See online at https://doi.org/10.7326/0003-4819-155-5-201109060-00026)
• (2011). Toward the blood-borne miRNome of human diseases. Nat Methods. 8(10):841-3
  Keller A, Leidinger P, Bauer A, Elsharawy A, Haas J, Backes C, Wendschlag A, Giese N, Tjaden C, Ott K, Werner J, Hackert T, Ruprecht K, Huwer H, Huebers J, Jacobs G, Rosenstiel P, Dommisch H, Schaefer A, Müller-Quernheim J, Wullich B, Keck B, Graf N, Reichrath J, Vogel B, Nebel A, Jager SU, Staehler P, Amarantos I, Boisguerin V, Staehler C, Beier M, Scheffler M, Büchler MW, Wischhusen J, Haeusler SF, Dietl J, Hofmann S, Lenhof HP, Schreiber S, Katus HA, Rottbauer W, Meder B, Hoheisel JD, Franke A, Meese E
  (See online at https://doi.org/10.1038/nmeth.1682)
• (2011). Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis. Gastroenterology. 141(1):227-36
  Lepage P, Häsler R, Spehlmann ME, Rehman A, Zvirbliene A, Begun A, Ott S, Kupcinskas L, Doré J, Raedler A, Schreiber S
  (See online at https://doi.org/10.1053/j.gastro.2011.04.011)
• 2011). Human metabolic individuality in biomedical and pharmaceutical research. Nature. 477(7362):54-60
  Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, Wägele B, Altmaier E; CARDIoGRAM, Deloukas P, Erdmann J, Grundberg E, Hammond CJ, de Angelis MH, Kastenmüller G, Köttgen A, Kronenberg F, Mangino M, Meisinger C, Meitinger T, Mewes HW, Milburn MV, Prehn C, Raffler J, Ried JS, Römisch-Margl W, Samani NJ, Small KS, Wichmann HE, Zhai G, Illig T, Spector TD, Adamski J, Soranzo N, Gieger C
  (See online at https://doi.org/10.1038/nature10354)
• 2011). Improvement of treatment-refractory atopic dermatitis by immunoadsorption: a pilot study. J Allergy Clin Immunol. 127(1):267-70, 270.e1-6
  Kasperkiewicz M, Schmidt E, Frambach Y, Rose C, Meier M, Nitschke M, Falk TM, Reich K, Ludwig RJ, Zillikens D
  (See online at https://doi.org/10.1016/j.jaci.2010.07.042)
• (2012). Abatacept for Crohn's disease and ulcerative colitis. Gastroenterology. 143(1):62-69.e4
  Sandborn WJ, Colombel JF, Sands BE, Rutgeerts P, Targan SR, Panaccione R, Bressler B, Geboes K, Schreiber S, Aranda R, Gujrathi S, Luo A, Peng Y, Salter-Cid L, Hanauer SB
  (See online at https://doi.org/10.1053/j.gastro.2012.04.010)
• (2012). ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature. 487(7408):477-81
  Hashimoto T, Perlot T, Rehman A, Trichereau J, Ishiguro H, Paolino M, Sigl V, Hanada T, Hanada R, Lipinski S, Wild B, Camargo SM, Singer D, Richter A, Kuba K, Fukamizu A, Schreiber S, Clevers H, Verrey F, Rosenstiel P, Penninger JM
  (See online at https://doi.org/10.1038/nature11228)
• (2012). Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1. Nat Med. 18(9):1401-6
  Karsten CM, Pandey MK, Figge J, Kilchenstein R, Taylor PR, Rosas M, McDonald JU, Orr SJ, Berger M, Petzold D, Blanchard V, Winkler A, Hess C, Reid DM, Majoul IV, Strait RT, Harris NL, Köhl G, Wex E, Ludwig R, Zillikens D, Nimmerjahn F, Finkelman FD, Brown GD, Ehlers M, Köhl J
  (See online at https://doi.org/10.1038/nm.2862)
• (2012). Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 491(7422):119-24
  Jostins L, ..., International IBD Genetics Consortium (IIBDGC), ..., Cho JH
  (See online at https://doi.org/10.1038/nature11582)
• (2012). Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet. 44(12):1341-8
  Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, Kang HM, Allen MH, McManus R, Novelli G, Samuelsson L, Schalkwijk J, Ståhle M, Burden AD, Smith CH, Cork MJ, Estivill X, Bowcock AM, Krueger GG, Weger W, Worthington J, Tazi-Ahnini R, Nestle FO, Hayday A, Hoffmann P, Winkelmann J, Wijmenga C, Langford C, Edkins S, Andrews R, Blackburn H, Strange A, Band G, Pearson RD, Vukcevic D, Spencer CC, Deloukas P, Mrowietz U, Schreiber S, Weidinger S, Koks S, Kingo K, Esko T, Metspalu A, Lim HW, Voorhees JJ, Weichenthal M, Wichmann HE, Chandran V, Rosen CF, Rahman P, Gladman DD, Griffiths CE, Reis A, Kere J; Collaborative Association Study of Psoriasis (CASP); Genetic Analysis of Psoriasis Consortium; Psoriasis Association Genetics Extension; Wellcome Trust Case Control Consortium 2, Nair RP, Franke A, Barker JN, Abecasis GR, Elder JT, Trembath RC
  (See online at https://doi.org/10.1038/ng.2467)
• (2012). The CD46- Jagged1 interaction is critical for human TH1 immunity. Nat Immunol. 13(12):1213-21
  Le Friec G, Sheppard D, Whiteman P, Karsten CM, Shamoun SA, Laing A, Bugeon L, Dallman MJ, Melchionna T, Chillakuri C, Smith RA, Drouet C, Couzi L, Fremeaux-Bacchi V, Köhl J, Waddington SN, McDonnell JM, Baker A, Handford PA, Lea SM, Kemper C
  (See online at https://doi.org/10.1038/ni.2454)
• (2012). Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med. 367(16):1519-28
  Sandborn WJ, Gasink C, Gao LL, Blank MA, Johanns J, Guzzo C, Sands BE, Hanauer SB, Targan S, Rutgeerts P, Ghosh S, de Villiers WJ, Panaccione R, Greenberg G, Schreiber S, Lichtiger S, Feagan BG; CERTIFI Study Group
  (See online at https://doi.org/10.1056/NEJMoa1203572)
• (2013). Dysfunctional nitric oxide signalling increases risk of myocardial infarction. Nature. 504(7480):432-6
  Erdmann J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, Kaiser FJ, Braunholz D, Medack A, Fischer M, Zimmermann ME, Tennstedt S, Graf E, Eck S, Aherrahrou Z, Nahrstaedt J, Willenborg C, Bruse P, Brænne I, Nöthen MM, Hofmann P, Braund PS, Mergia E, Reinhard W, Burgdorf C, Schreiber S, Balmforth AJ, Hall AS, Bertram L, Steinhagen-Thiessen E, Li SC, März W, Reilly M, Kathiresan S, McPherson R, Walter U; CARDIoGRAM, Ott J, Samani NJ, Strom TM, Meitinger T, Hengstenberg C, Schunkert H
  (See online at https://doi.org/10.1038/nature12722)
• (2013). Genomewide mapping of gene-microbiota interactions in susceptibility to autoimmune skin blistering. Nat Commun. 4:2462
  Srinivas G, Möller S, Wang J, Künzel S, Zillikens D, Baines JF, Ibrahim SM
  (See online at https://doi.org/10.1038/ncomms3462)
• (2013). High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. Nat Genet. 45(7):808-12
  Ellinghaus D, Baurecht H, Esparza-Gordillo J, Rodríguez E, Matanovic A, Marenholz I, Hübner N, Schaarschmidt H, Novak N, Michel S, Maintz L, Werfel T, Meyer-Hoffert U, Hotze M, Prokisch H, Heim K, Herder C, Hirota T, Tamari M, Kubo M, Takahashi A, Nakamura Y, Tsoi LC, Stuart P, Elder JT, Sun L, Zuo X, Yang S, Zhang X, Hoffmann P, Nöthen MM, Fölster-Holst R, Winkelmann J, Illig T, Boehm BO, Duerr RH, Büning C, Brand S, Glas J, McAleer MA, Fahy CM, Kabesch M, Brown S, McLean WH, Irvine AD, Schreiber S, Lee YA, Franke A, Weidinger S
  (See online at https://doi.org/10.1038/ng.2642)
• (2013). mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease. Gut. 62(3):376-86
  Derer S, Till A, Haesler R, Sina C, Grabe N, Jung S, Nikolaus S, Kuehbacher T, Groetzinger J, Rose-John S, Rosenstiel PC, Schreiber S
  (See online at https://doi.org/10.1136/gutjnl-2011-300384)
• (2013). NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J Clin Invest. 123(2):700-11
  Couturier-Maillard A, Secher T, Rehman A, Normand S, De Arcangelis A, Haesler R, Huot L, Grandjean T, Bressenot A, Delanoye-Crespin A, Gaillot O, Schreiber S, Lemoine Y, Ryffel B, Hot D, Nùñez G, Chen G, Rosenstiel P, Chamaillard M
  (See online at https://doi.org/10.1172/JCI62236)
• (2013). Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans. Nat Genet. 45(10):1176-82
  Comas I, Coscolla M, Luo T, Borrell S, Holt KE, Kato-Maeda M, Parkhill J, Malla B, Berg S, Thwaites G, Yeboah-Manu D, Bothamley G, Mei J, Wei L, Bentley S, Harris SR, Niemann S, Diel R, Aseffa A, Gao Q, Young D, Gagneux S
  (See online at https://doi.org/10.1038/ng.2744)
• (2013). Paneth cells as a site of origin for intestinal inflammation. Nature. 503(7475):272-6
  Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann- Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS
  (See online at https://doi.org/10.1038/nature12599)
• (2013). T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies. J Clin Invest. 123(9):3788-96
  Hess C, Winkler A, Lorenz AK, Holecska V, Blanchard V, Eiglmeier S, Schoen AL, Bitterling J, Stoehr AD, Petzold D, Schommartz T, Mertes MM, Schoen CT, Tiburzy B, Herrmann A, Köhl J, Manz RA, Madaio MP, Berger M, Wardemann H, Ehlers M
  (See online at https://doi.org/10.1172/JCI65938)
• (2013). Transcriptome and genome sequencing uncovers functional variation in humans. Nature. 501(7468):506-11
  Lappalainen T, Sammeth M, Friedländer MR, 't Hoen PA, Monlong J, Rivas MA, Gonzàlez- Porta M, Kurbatova N, Griebel T, Ferreira PG, Barann M, Wieland T, Greger L, van Iterson M, Almlöf J, Ribeca P, Pulyakhina I, Esser D, Giger T, Tikhonov A, Sultan M, Bertier G, MacArthur DG, Lek M, Lizano E, Buermans HP, Padioleau I, Schwarzmayr T, Karlberg O, Ongen H, Kilpinen H, Beltran S, Gut M, Kahlem K, Amstislavskiy V, Stegle O, Pirinen M, Montgomery SB, Donnelly P, McCarthy MI, Flicek P, Strom TM; Geuvadis Consortium, Lehrach H, Schreiber S, Sudbrak R, Carracedo A, Antonarakis SE, Häsler R, Syvänen AC, van Ommen GJ, Brazma A, Meitinger T, Rosenstiel P, Guigó R, Gut IG, Estivill X, Dermitzakis ET
  (See online at https://doi.org/10.1038/nature12531)
• (2013). When the most potent combination of antibiotics selects for the greatest bacterial load: the smile-frown transition. PLoS Biol. 11(4):e1001540
  Pena-Miller R, Laehnemann D, Jansen G, Fuentes-Hernandez A, Rosenstiel P, Schulenburg H, Beardmore R
  (See online at https://doi.org/10.1371/journal.pbio.1001540)
• (2014). Dupilumab treatment in adults with moderateto-severe atopic dermatitis. N Engl J Med. 371(2):130-9
  Beck LA, Thaçi D, Hamilton JD, Graham NM, Bieber T, Rocklin R, Ming JE, Ren H, Kao R, Simpson E, Ardeleanu M, Weinstein SP, Pirozzi G, Guttman-Yassky E, Suárez-Fariñas M, Hager MD, Stahl N, Yancopoulos GD, Radin AR
  (See online at https://doi.org/10.1056/NEJMoa1314768)
• (2014). Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial. Lancet. 384(9940):309-18
  Vermeire S, O'Byrne S, Keir M, Williams M, Lu TT, Mansfield JC, Lamb CA, Feagan BG, Panes J, Salas A, Baumgart DC, Schreiber S, Dotan I, Sandborn WJ, Tew GW, Luca D, Tang MT, Diehl L, Eastham-Anderson J, De Hertogh G, Perrier C, Egen JG, Kirby JA, van Assche G, Rutgeerts P
  (See online at https://doi.org/10.1016/S0140-6736(14)60661-9)
• (2014). Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE. J Clin Invest. 124(5):2188-92
  Chen H, Assmann JC, Krenz A, Rahman M, Grimm M, Karsten CM, Köhl J, Offermanns S, Wettschureck N, Schwaninger M
  (See online at https://doi.org/10.1172/JCI72151)
• (2015). A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy. Nat Commun. 6:6784
  Karpf S, Eibl M, Wieser W, Klein T, Huber R
  (See online at https://doi.org/10.1038/ncomms7784)
• (2015). Analysis of intestinal microbiota in hybrid house mice reveals evolutionary divergence in a vertebrate hologenome. Nat Commun. 6:6440
  Wang J, Kalyan S, Steck N, Turner LM, Harr B, Künzel S, Vallier M, Häsler R, Franke A, Oberg HH, Ibrahim SM, Grassl GA, Kabelitz D, Baines JF
  (See online at https://doi.org/10.1038/ncomms7440)
• (2015). Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat Genet. 47(9):979-986
  Liu JZ, van Sommeren S, Huang H, Ng SC, Alberts R, Takahashi A, Ripke S, Lee JC, Jostins L, Shah T, Abedian S, Cheon JH, Cho J, Dayani NE, Franke L, Fuyuno Y, Hart A, Juyal RC, Juyal G, Kim WH, Morris AP, Poustchi H, Newman WG, Midha V, Orchard TR, Vahedi H, Sood A, Sung JY, Malekzadeh R, Westra HJ, Yamazaki K, Yang SK; International Multiple Sclerosis Genetics Consortium; International IBD Genetics Consortium, Barrett JC, Alizadeh BZ, Parkes M, Bk T, Daly MJ, Kubo M, Anderson CA, Weersma RK
  (See online at https://doi.org/10.1038/ng.3359)
• (2015). Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance. Cell Metab. 21(3):403-16
  Kraakman MJ, Kammoun HL, Allen TL, Deswaerte V, Henstridge DC, Estevez E, Matthews VB, Neill B, White DA, Murphy AJ, Peijs L, Yang C, Risis S, Bruce CR, Du XJ, Bobik A, Lee-Young RS, Kingwell BA, Vasanthakumar A, Shi W, Kallies A, Lancaster GI, Rose-John S, Febbraio MA
  (See online at https://doi.org/10.1016/j.cmet.2015.02.006)
• (2015). Detection of drug-resistant tuberculosis by Xpert MTB/RIF in Swaziland. N Engl J Med. 372(12):1181-2
  Sanchez-Padilla E, Merker M, Beckert P, Jochims F, Dlamini T, Kahn P, Bonnet M, Niemann S
  (See online at https://doi.org/10.1056/NEJMc1413930)
• (2015). Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage. Nat Genet. 47(3):242-9
  Merker M, Blin C, Mona S, Duforet-Frebourg N, Lecher S, Willery E, Blum MG, Rüsch-Gerdes S, Mokrousov I, Aleksic E, Allix-Béguec C, Antierens A, Augustynowicz-Kopeć E, Ballif M, Barletta F, Beck HP, Barry CE 3rd, Bonnet M, Borroni E, Campos-Herrero I, Cirillo D, Cox H, Crowe S, Crudu V, Diel R, Drobniewski F, Fauville-Dufaux M, Gagneux S, Ghebremichael S, Hanekom M, Hoffner S, Jiao WW, Kalon S, Kohl TA, Kontsevaya I, Lillebæk T, Maeda S, Nikolayevskyy V, Rasmussen M, Rastogi N, Samper S, Sanchez-Padilla E, Savic B, Shamputa IC, Shen A, Sng LH, Stakenas P, Toit K, Varaine F, Vukovic D, Wahl C, Warren R, Supply P, Niemann S, Wirth T
  (See online at https://doi.org/10.1038/ng.3195)
• (2015). Evolutionary Transition from Pathogenicity to Commensalism: Global Regulator Mutations Mediate Fitness Gains through Virulence Attenuation. Mol Biol Evol. 32(11):2883-96
  Jansen G, Crummenerl LL, Gilbert F, Mohr T, Pfefferkorn R, Thänert R, Rosenstiel P, Schulenburg H
  (See online at https://doi.org/10.1093/molbev/msv160)
• (2015). High-density mapping of the MHC identifies a shared role for HLA-DRB101:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Nat Genet. 47(2):172-9
  Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L, Huang H, Ripke S, Gusareva ES, Annese V, Hauser SL, Oksenberg JR, Thomsen I, Leslie S; International Inflammatory Bowel Disease Genetics Consortium; Australia and New Zealand IBDGC; Belgium IBD Genetics Consortium; Italian Group for IBD Genetic Consortium; NIDDK Inflammatory Bowel Disease Genetics Consortium; United Kingdom IBDGC; Wellcome Trust Case Control Consortium; Quebec IBD Genetics Consortium, Daly MJ, Van Steen K, Duerr RH, Barrett JC, McGovern DP, Schumm LP, Traherne JA, Carrington MN, Kosmoliaptsis V, Karlsen TH, Franke A, Rioux JD
  (See online at https://doi.org/10.1038/ng.3176)
• (2015). IgG1 protects against renal disease in a mouse model of cryoglobulinaemia. Nature. 517(7535):501-4
  Strait RT, Posgai MT, Mahler A, Barasa N, Jacob CO, Köhl J, Ehlers M, Stringer K, Shanmukhappa SK, Witte D, Hossain MM, Khodoun M, Herr AB, Finkelman FD
  (See online at https://doi.org/10.1038/nature13868)
• (2015). Using a sequential regimen to eliminate bacteria at sublethal antibiotic dosages. PLoS Biol. 13(4):e1002104
  Fuentes-Hernandez A, Plucain J, Gori F, Pena-Miller R, Reding C, Jansen G, Schulenburg H, Gudelj I, Beardmore R
  (See online at https://doi.org/10.1371/journal.pbio.1002104)
• (2015). Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases. Nat Genet. 47(9):1085-90
  Lenz TL, Deutsch AJ, Han B, Hu X, Okada Y, Eyre S, Knapp M, Zhernakova A, Huizinga TW, Abecasis G, Becker J, Boeckxstaens GE, Chen WM, Franke A, Gladman DD, Gockel I, Gutierrez-Achury J, Martin J, Nair RP, Nöthen MM, Onengut-Gumuscu S, Rahman P, Rantapää- Dahlqvist S, Stuart PE, Tsoi LC, van Heel DA, Worthington J, Wouters MM, Klareskog L, Elder JT, Gregersen PK, Schumacher J, Rich SS, Wijmenga C, Sunyaev SR, de Bakker PI, Raychaudhuri S
  (See online at https://doi.org/10.1038/ng.3379)
• Multiancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat Genet. 47(12):1449-1456
  Paternoster L, ..., Australian Asthma Genetics Consortium (AAGC), ..., Weidinger S
  (See online at https://doi.org/10.1038/ng.3424)
• (2016). Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nat Genet. 48(5):510-8
  Ellinghaus D, ..., Franke A
  (See online at https://doi.org/10.1038/ng.3528)
• (2016). Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial. Lancet. 387(10013):40-52
  Thaçi D, Simpson EL, Beck LA, Bieber T, Blauvelt A, Papp K, Soong W, Worm M, Szepietowski JC, Sofen H, Kawashima M, Wu R, Weinstein SP, Graham NM, Pirozzi G, Teper A, Sutherland ER, Mastey V, Stahl N, Yancopoulos GD, Ardeleanu M
  (See online at https://doi.org/10.1016/S0140-6736(15)00388-8)
• (2016). Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development. Immunity. 45(5):1148-1161
  Durek P, Nordström K, Gasparoni G, Salhab A, Kressler C, de Almeida M, Bassler K, Ulas T, Schmidt F, Xiong J, Glažar P, Klironomos F, Sinha A, Kinkley S, Yang X, Arrigoni L, Amirabad AD, Ardakani FB, Feuerbach L, Gorka O, Ebert P, Müller F, Li N, Frischbutter S, Schlickeiser S, Cendon C, Fröhler S, Felder B, Gasparoni N, Imbusch CD, Hutter B, Zipprich G, Tauchmann Y, Reinke S, Wassilew G, Hoffmann U, Richter AS, Sieverling L; DEEP Consortium, Chang HD, Syrbe U, Kalus U, Eils J, Brors B, Manke T, Ruland J, Lengauer T, Rajewsky N, Chen W, Dong J, Sawitzki B, Chung HR, Rosenstiel P, Schulz MH, Schultze JL, Radbruch A, Walter J, Hamann A, Polansky JK
  (See online at https://doi.org/10.1016/j.immuni.2016.10.022)
• (2016). Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota. Nat Genet. 48(11):1396-1406
  Wang J, Thingholm LB, Skiecevičienė J, Rausch P, Kummen M, Hov JR, Degenhardt F, Heinsen FA, Rühlemann MC, Szymczak S, Holm K, Esko T, Sun J, Pricop-Jeckstadt M, Al-Dury S, Bohov P, Bethune J, Sommer F, Ellinghaus D, Berge RK, Hübenthal M, Koch M, Schwarz K, Rimbach G, Hübbe P, Pan WH, Sheibani-Tezerji R, Häsler R, Rosenstiel P, D'Amato M, Cloppenborg-Schmidt K, Künzel S, Laudes M, Marschall HU, Lieb W, Nöthlings U, Karlsen TH, Baines JF, Franke A
  (See online at https://doi.org/10.1038/ng.3695)
• (2016). Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus. Ann Rheum Dis. 75(7):1407-15
  von Spee-Mayer C, Siegert E, Abdirama D, Rose A, Klaus A, Alexander T, Enghard P, Sawitzki B, Hiepe F, Radbruch A, Burmester GR, Riemekasten G, Humrich JY
  (See online at https://doi.org/10.1136/annrheumdis-2015-207776)
• (2016). NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature. 540(7634):583-587
  Karki R, Man SM, Malireddi RKS, Kesavardhana S, Zhu Q, Burton AR, Sharma BR, Qi X, Pelletier S, Vogel P, Rosenstiel P, Kanneganti TD
  (See online at https://doi.org/10.1038/nature20597)
• (2016). T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells. Science. 352(6292):aad1210
  Arbore G, West EE, Spolski R, Robertson AAB, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O'Neill LA, Coll RC, Sher A, Leonard WJ, Köhl J, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber KD, Kemper C
  (See online at https://doi.org/10.1126/science.aad1210)
• (2016). Treatment Outcomes in Multidrug-Resistant Tuberculosis. N Engl J Med. 375(11):1103-5
  Günther G, Lange C, Alexandru S, Altet N, Avsar K, Bang D, Barbuta R, Bothamley G, Ciobanu A, Crudu V, Danilovits M, Dedicoat M, Duarte R, Gualano G, Kunst H, de Lange W, Leimane V, Magis-Escurra C, McLaughlin AM, Muylle I, Polcová V, Popa C, Rumetshofer R, Skrahina A, Solodovnikova V, Spinu V, Tiberi S, Viiklepp P, van Leth F; for TBNET
  (See online at https://doi.org/10.1056/NEJMc1603274)
• (2017). Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol. 18(1):74-85
  Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller- Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T
  (See online at https://doi.org/10.1038/ni.3632)
• adelli M, Engstrand L, Linz B, Moritz RL, Grimm R, Krause J, Nebel A, Moodley Y, Rattei T, Zink A (2016). The 5300-year-old Helicobacter pylori genome of the Iceman. Science. 351(6269):162-165
  Maixner F, Krause-Kyora B, Turaev D, Herbig A, Hoopmann MR, Hallows JL, Kusebauch U, Vigl EE, Malfertheiner P, Megraud F, O'Sullivan N, Cipollini G, Coia V, Samadelli M, Engstrand L, Linz B, Moritz RL, Grimm R, Krause J, Nebel A, Moodley Y, Rattei T, Zink A
  (See online at https://doi.org/10.1126/science.aad2545)
• (2017). A secreted antibacterial neuropeptide shapes the microbiome of Hydra. Nat Commun. 8(1):698
  Augustin R, Schröder K, Murillo Rincón AP, Fraune S, Anton-Erxleben F, Herbst EM, Wittlieb J, Schwentner M, Grötzinger J, Wassenaar TM, Bosch TCG
  (See online at https://doi.org/10.1038/s41467-017-00625-1)
• (2017). Clinical remission in patients with moderate-to-severe Crohn's disease treated with filgotinib (the FITZROY study): results from a phase 2, double-blind, randomised, placebocontrolled trial. Lancet. 389(10066):266-275
  Vermeire S, Schreiber S, Petryka R, Kuehbacher T, Hebuterne X, Roblin X, Klopocka M, Goldis A, Wisniewska-Jarosinska M, Baranovsky A, Sike R, Stoyanova K, Tasset C, Van der Aa A, Harrison P
  (See online at https://doi.org/10.1016/S0140-6736(16)32537-5)
• (2017). Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease. Nature. 543(7643):108-112
  Pandey MK, Burrow TA, Rani R, Martin LJ, Witte D, Setchell KD, Mckay MA, Magnusen AF, Zhang W, Liou B, Köhl J, Grabowski GA
  (See online at https://doi.org/10.1038/nature21368)
• (2017). D-tryptophan from probiotic bacteria influences the gut microbiome and allergic airway disease. J Allergy Clin Immunol. 139(5):1525-1535
  Kepert I, Fonseca J, Müller C, Milger K, Hochwind K, Kostric M, Fedoseeva M, Ohnmacht C, Dehmel S, Nathan P, Bartel S, Eickelberg O, Schloter M, Hartmann A, Schmitt-Kopplin P, Krauss-Etschmann S
  (See online at https://doi.org/10.1016/j.jaci.2016.09.003)
• (2017). Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis. J Exp Med. 214(2):401-422
  Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A
  (See online at https://doi.org/10.1084/jem.20160791)
• (2017). Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients with Clostridium difficile Infection. Gastroenterology. 152(4):799-811.e7
  Ott SJ, Waetzig GH, Rehman A, Moltzau-Anderson J, Bharti R, Grasis JA, Cassidy L, Tholey A, Fickenscher H, Seegert D, Rosenstiel P, Schreiber S
  (See online at https://doi.org/10.1053/j.gastro.2016.11.010)
• (2017). Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases. Gastroenterology. 153(6):1504-1516.e2
  Nikolaus S, Schulte B, Al-Massad N, Thieme F, Schulte DM, Bethge J, Rehman A, Tran F, Aden K, Häsler R, Moll N, Schütze G, Schwarz MJ, Waetzig GH, Rosenstiel P, Krawczak M, Szymczak S, Schreiber S
  (See online at https://doi.org/10.1053/j.gastro.2017.08.028)
• (2017). Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation. PLoS Biol. 15(1):e2000080
  Riethmueller S, Somasundaram P, Ehlers JC, Hung CW, Flynn CM, Lokau J, Agthe M, Düsterhöft S, Zhu Y, Grötzinger J, Lorenzen I, Koudelka T, Yamamoto K, Pickhinke U, Wichert R, Becker-Pauly C, Rädisch M, Albrecht A, Hessefort M, Stahnke D, Unverzagt C, Rose-John S, Tholey A, Garbers C
  (See online at https://doi.org/10.1371/journal.pbio.2000080)
• (2017). Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis. N Engl J Med. 376(18):1723-1736
  Sandborn WJ, Su C, Sands BE, D'Haens GR, Vermeire S, Schreiber S, Danese S, Feagan BG, Reinisch W, Niezychowski W, Friedman G, Lawendy N, Yu D, Woodworth D, Mukherjee A, Zhang H, Healey P, Panés J; OCTAVE Induction 1, OCTAVE Induction 2, and OCTAVE Sustain Investigators
  (See online at https://doi.org/10.1056/NEJMoa1606910)
• (2017). Uncoupling of mucosal gene regulation, mRNA splicing and adherent microbiota signatures in inflammatory bowel disease. Gut. 66(12):2087-2097
  Häsler R, Sheibani-Tezerji R, Sinha A, Barann M, Rehman A, Esser D, Aden K, Knecht C, Brandt B, Nikolaus S, Schäuble S, Kaleta C, Franke A, Fretter C, Müller W, Hütt MT, Krawczak M, Schreiber S, Rosenstiel P
  (See online at https://doi.org/10.1136/gutjnl-2016-311651)
• (2018). A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study. Lancet Infect Dis. 18(4):431-440
  Walker TM, Merker M, Knoblauch AM, Helbling P, Schoch OD, van der Werf MJ, Kranzer K, Fiebig L, Kröger S, Haas W, Hoffmann H, Indra A, Egli A, Cirillo DM, Robert J, Rogers TR, Groenheit R, Mengshoel AT, Mathys V, Haanperä M, Soolingen DV, Niemann S, Böttger EC, Keller PM; MDR-TB Cluster Consortium
  (See online at https://doi.org/10.1016/S1473-3099(18)30004-5)
• (2018). Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans. Nat Commun. 9(1):1569
  Krause-Kyora B, Nutsua M, Boehme L, Pierini F, Pedersen DD, Kornell SC, Drichel D, Bonazzi M, Möbus L, Tarp P, Susat J, Bosse E, Willburger B, Schmidt AH, Sauter J, Franke A, Wittig M, Caliebe A, Nothnagel M, Schreiber S, Boldsen JL, Lenz TL, Nebel A
  (See online at https://doi.org/10.1038/s41467-018-03857-x)
• (2018). Anti-inflammatory effects of roflumilast in chronic obstructive pulmonary disease (ROBERT): a 16-week, randomised, placebo-controlled trial. Lancet Respir Med. 6(11):827-836
  Rabe KF, Watz H, Baraldo S, Pedersen F, Biondini D, Bagul N, Hanauer G, Göhring UM, Purkayastha D, Román J, Alagappan VKT, Saetta M
  (See online at https://doi.org/10.1016/S2213-2600(18)30331-X)
• (2018). Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma. N Engl J Med. 378(26):2475-2485
  Rabe KF, Nair P, Brusselle G, Maspero JF, Castro M, Sher L, Zhu H, Hamilton JD, Swanson BN, Khan A, Chao J, Staudinger H, Pirozzi G, Antoni C, Amin N, Ruddy M, Akinlade B, Graham NMH, Stahl N, Yancopoulos GD, Teper A
  (See online at https://doi.org/10.1056/NEJMoa1804093)
• (2018). Epidermal lipid composition, barrier integrity, and eczematous inflammation are associated with skin microbiome configuration. J Allergy Clin Immunol. 141(5):1668-1676.e16
  Baurecht H, Rühlemann MC, Rodríguez E, Thielking F, Harder I, Erkens AS, Stölzl D, Ellinghaus E, Hotze M, Lieb W, Wang S, Heinsen-Groth FA, Franke A, Weidinger S
  (See online at https://doi.org/10.1016/j.jaci.2018.01.019)
• (2018). Revising the definition of extensively drug-resistant tuberculosis. Lancet Respir Med. 6(12):893-895
  Lange C, Chesov D, Furin J, Udwadia Z, Dheda K
  (See online at https://doi.org/10.1016/S2213-2600(18)30428-4)
• (2018). Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions. J Allergy Clin Immunol. 141(1):399-402.e8
  Epp A, Hobusch J, Bartsch YC, Petry J, Lilienthal GM, Koeleman CAM, Eschweiler S, Möbs C, Hall A, Morris SC, Braumann D, Engellenner C, Bitterling J, Rahmöller J, Leliavski A, Thurmann R, Collin M, Moremen KW, Strait RT, Blanchard V, Petersen A, Gemoll T, Habermann JK, Petersen F, Nandy A, Kahlert H, Hertl M, Wuhrer M, Pfützner W, Jappe U, Finkelman FD, Ehlers M
  (See online at https://doi.org/10.1016/j.jaci.2017.06.021)
• (2018). Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans. Diabetes Care. 41(3):398-405
  Fangmann D, Theismann EM, Türk K, Schulte DM, Relling I, Hartmann K, Keppler JK, Knipp JR, Rehman A, Heinsen FA, Franke A, Lenk L, Freitag-Wolf S, Appel E, Gorb S, Brenner C, Seegert D, Waetzig GH, Rosenstiel P, Schreiber S, Schwarz K, Laudes M
  (See online at https://doi.org/10.2337/dc17-1967)
• (2018). Tiotropium and olodaterol in the prevention of chronic obstructive pulmonary disease exacerbations (DYNAGITO): a double-blind, randomised, parallel-group, active-controlled trial. Lancet Respir Med. 6(5):337-344
  Calverley PMA, Anzueto AR, Carter K, Grönke L, Hallmann C, Jenkins C, Wedzicha J, Rabe KF
  (See online at https://doi.org/10.1016/S2213-2600(18)30102-4)
• (2018). Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly. Nat Commun. 9(1):327
  Aramillo Irizar P, Schäuble S, Esser D, Groth M, Frahm C, Priebe S, Baumgart M, Hartmann N, Marthandan S, Menzel U, Müller J, Schmidt S, Ast V, Caliebe A, König R, Krawczak M, Ristow M, Schuster S, Cellerino A, Diekmann S, Englert C, Hemmerich P, Sühnel J, Guthke R, Witte OW, Platzer M, Ruppin E, Kaleta C
  (See online at https://doi.org/10.1038/s41467-017-02395-2)