How cell death shapes tumor evolution during carcinogenesis (C01 [B06])

• Subject Area: Evolutionary Cell and Developmental Biology (Zoology)
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 325931972

The project will quantitatively analyze the role of cell death in tumor evolution. How does cell death and its potential loss affect cancer evolution, specifically the clonal heterogeneity and fitness of tumors? Our approach combines in vitro and in vivo work on cell death pathways, clonal analyses, and a fitness model for cell death pathways to map and predict trajectories of cell death pathway inactivation in cancer.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1310: Predictability in Evolution
• Applicant Institution: Universität zu Köln
• Project Heads: Professor Dr. Johannes Berg, since 1/2022; Professorin Dr. Silvia von Karstedt, since 1/2022