Timed targeting of cGAS / STING to improve tissue-regeneration and anti-tumor responses following allo-HSCT (A08*)

• Subject Area: Hematology, Oncology ; Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 324392634

The impact of selective and timed activation or inhibition of the type I interferon inducing cGAS / STING pathway during the course of allo-HSCT and its influence on the GvL effect as well as donor T cell activation and differentiation remains unknown. Using selective receptor ligands and inhibitors, and a combination of advanced in vivo models of leukemia and lymphoma, allogeneic transplantation models, and next-generation sequencing approaches, we aim to unravel the consequences of timed cGAS/STING activation / inhibition during allo-HSCT.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 221: Modulation of graft-versus-host and graft-versus-leukemia immune responses after allogeneic stem cell transplantation
• Applicant Institution: Universität Regensburg
• Project Heads: Professor Dr. Hendrik Poeck; Dr. Christian Schmidl