Timed targeting of cGAS/STING to improve tissue regeneration and anti-tumor responses following ASCT (A08)

• Subject Area: Hematology, Oncology ; Immunology ; Clinical Immunology and Allergology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 324392634

The impact of timed cGAS/STING pathway activation or inhibition during ASCT on GvL responses and donor T cell function remains unclear. To dissect time-dependent cGAS/STING effects during ASCT, we use selective receptor ligands and inhibitors, microbial metabolites and preclinical leukemia/lymphoma and allo-transplant models, integrated with next-generation sequencing analyses. These findings could guide clinical translation of cGAS/STING-targeted interventions in ASCT.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 221: Modulation of graft-versus-host and graft-versus-leukemia immune responses after allogeneic stem cell transplantation
• Applicant Institution: Universität Regensburg
• Project Heads: Professor Dr. Hendrik Poeck; Dr. Christian Schmidl