Role of β2-adrenergic- and natriuretic peptide receptor- induced signalling in CD4+ T-cells after myocardial infarction (B01)

• Subject Area: Cardiology, Angiology ; Cell Biology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 453989101

The project aims to understand how adrenergic and natriuretic peptide signalling contributes to T-cell responses during myocardial infarction (MI). Genetic manipulation of these pathways and adoptive cell trans- fer experiments will be employed in a mouse model of MI. Our results can shed light on the neuroendocrine regulation of T-cells within the infarcted milieu.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1525: Cardio-Immune Interfaces
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Dr. Stefan Frantz; Professor Dr. Viacheslav Nikolaev