ANP-mediated cardiomyocyte-endothelial cell cross-talk (wrong-talk?): role in ischemia/reperfusion-induced activation of immune cells (B02)

• Subject Area: Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 453989101

This project will dissect the effects of cardiac natriuretic peptides on myocardial microcirculatory and endothelial barrier functions. Our data reveal that hypoxia and cytokines alter endothelial natriuretic peptide signalling and actions. This may contribute to vascular hyperpermeability, oedema, leucocyte recruitment and extravasation in cardiac ischemia-reperfusion injury. Dissection of such molecular and functional alterations may help to develop antiinflammatory strategies targeting the coronary microcirculation in reperfused acute myocardial infarction.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1525: Cardio-Immune Interfaces
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Head: Professorin Dr. Michaela Kuhn