Project Details
Projekt
Molecular basis of lipid transport across the periplasm (P03)
Subject Area
Biochemistry
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 450648163
The periplasm of Gram-negative bacteria is confined by the inner membrane (IM) composed of a bilayer of phospholipids and the outer membrane (OM), with an inner layer of phospholipids and an outer layer of mainly lipopolysaccharides. The preservation of the OM-lipid asymmetry is necessary to protect the cell from hydrophobic toxins and is in Campylobacter jejuni thought to be based on the transport of phospholipids between the IM and OM by an RND transport machinery and MlaA/MlaC homologs. In project P03, we will investigate the role of the putative lipid RND transporter, its dependence on MlaA and MlaC homologs, its structure, function, and the molecular mechanism of lipid transport through the periplasm.
DFG Programme
Collaborative Research Centres
Applicant Institution
Goethe-Universität Frankfurt am Main
Project Head
Professor Dr. Klaas Martinus Pos
