Quantitative super-resolution microscopy unravels nanoscale patterns of membrane receptor networks (P08)

• Subject Area: Biophysics
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450648163

Project P08 studies the composition and dynamics of receptor-ligand assemblies in their native cellular environment and will answer questions about structure-function relationships, ligand-driven selective activation, and protein-protein communication. To this end, we will employ super-resolution optical microscopy methods capable of visualizing multiple proteins and reporting on stoichiometries and spatial organization, as well as single-molecule imaging of protein assembly kinetics in living cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1507: Protein Assemblies and Machineries in Cell Membranes
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professor Dr. Mike Heilemann