Artificial intelligence-guided molecular dynamics simulations decipher the activation mechanism of cellular control programs (P09)

• Subject Area: Biophysics
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450648163

Project P09 will use modeling and simulations to gain a mechanistic understanding of fundamental regulatory processes. We will investigate the activation of the unfolded protein response (UPR), a pathway central in health and disease. We will establish artificial intelligence-guided simulations to understand how membrane-mediated interactions control the activation of the UPR. Furthermore, we will develop an interdisciplinary strategy to unravel the dimerization and activation of MET receptors.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1507: Protein Assemblies and Machineries in Cell Membranes
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Dr. Roberto Covino