Metabolic regulation of the endothelial cell damage responses (A02)

• Subject Area: Anatomy and Physiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 456687919

Metabolic reprogramming of endothelial cells co-determines their response to injury and the decision to promote or inhibit angiogenesis. This project addresses the hypothesis that sub-clusters of cardiac endothelial cells with unique metabolic signatures drive vascular responses to cardiac damage via the regulation of chromatin accessibility and gene transcription. We aim to determine whether endothelial 5-methyltetrahydrofolate (Slc19a1) and cystine (Slc7a11) transporters which are highly expressed in a sub-cluster of cardiac endothelial cells during the acute phase of injury, regulate endothelial transcription through histone modifications to drive cardiac revascularization.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1531: Damage control by the stroma-vascular compartment
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professorin Dr. Sofia Iris Bibli, Ph.D.