Gating and expression of long-term synaptic plasticity as an interplay between parallel transmission sites and astrocyte signaling (B11)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

During the second funding period, we investigated how different synaptic states relate to plasticity in cortical neurons, focusing on silent synapses. In the third funding period, we propose to delineate the plasticity mechanisms that are gated by synapse idling. We aim to identify how new transmission sites are generated and unsilenced. We will focus on several mechanisms, including the role of astrocyte activation by Gq signaling, which is sufficient to trigger new silent synapses.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Oliver M. Schlüter