Organ-specific priming during granulopoiesis generates neutrophil subsets (A01)

• Subject Area: Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 449437943

Neutrophils are traditionally been looked upon as a homogenous population of short-lived, end-differentiated, and transcriptionally silent leukocytes. In this project, we will develop a concept of neutrophil heterogeneity based on the organ-dependent specification of neutrophil progenitors to differentiate into distinct neutrophil lineages. Multi-omics analyses and functional studies will reveal the contribution of splenic and bone marrow neutrophils to regulation of the immune response and tissue damage during inflammation.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 332: Neutrophils: origin, fate and function
• Applicant Institution: Universität Münster
• Project Head: Dr. Carlos Silvestre-Roig, Ph.D., since 7/2022