Neutrophil-intrinsic control of immune activity (B03)

• Subject Area: Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 449437943

Because neutrophils operate with poor target precision, their activity must be tightly controlled. Recently, we showed that the transcription factor PU.1 shields the chromatin from indiscriminate transcriptional activity, thus safeguarding neutrophils from carrying out an inappropriate immune response. Yet, how neutrophils overcome this PU.1-instructed ‘chromatin barrier’ in infectious situations remains unexplored. Hence, we will here study epigenetic mechanisms operating in neutrophils to fine-tune their activity states during infection and inflammation.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 332: Neutrophils: origin, fate and function
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Frank Rosenbauer, since 7/2022