Innate immune memory of neutrophils during inflammation (B05)

• Subject Area: Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 449437943

Molecular pathways underlying neutrophil diversity remain ill-defined. In this project we will follow the hypothesis that mechanisms of innate immune memory prime the functional phenotype of neutrophils regarding their subsequent response patterns; a process which may be relevant during development of myeloid stem cells as well as during repetitive stimulation of mature (sub)-populations of neutrophils. The long-term goal of our project is the targeted manipulation of innate immune memory mechanisms in neutrophils for treatment of inflammatory diseases.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 332: Neutrophils: origin, fate and function
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Johannes Roth, since 7/2022