Photoinduced regio- and enantio-selective C-N coupling of unactivated secondary alkyl halides

• Applicant: Dr. Arup Mondal
• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 506385161

The aim of this project is the synthesis of a library of chemically and biologically highly important amino-acid type molecules in a regio- and enantioselective fashion. Novel synthesis method(s) are to be developed in order to construct such structures using light and appropriate ligands. For this purpose, a copper-catalyzed cleavage of usually challenging secondary carbon-halogen bond is to be performed regioselectively, where the regioselectivity between the inherently favored primary carbon-halogen and the challenging secondary carbon-halogen center will be tuned to favor the secondary carbon-halogen center either under a Curtin-Hammett type scenario or by using a directing group. Computational calculations are to be performed in order to gain a very detailed insight into the reaction mechanism. We expect the synthesized compounds will not only be useful for biological studies, but will also serve as a potential ligand library in the field of catalysis to develop new transformations.

• DFG Programme: WBP Fellowship
• International Connection: USA
• Host: Professor Gregory C. Fu, Ph.D.