Modelling and decoding the mechanisms of left ventricular non compaction cardiomyopathy (A04)

• Subject Area: Cardiology, Angiology
• Term: from 2022 to 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 464424253

Human left ventricular non-compaction cardiomyopathy (LVNC-CM) is a common, yet understudied, heart disease. Many LVNC-CM mutations impact developmental genes, including lamin A, suggesting that these cardiomyopathies have a developmental origin. Here, state-of-the-art 3D left-ventricle organoids and genome engineering are combined to model lamin A mutations. The impact of patient mutations on the differentiation and function of the left ventricle will be characterized using single-cell genomics. The impact of stress on the contractile properties of mutant organoids will be assessed. A04 will thereby reveal the mechanisms by which lamin A mutations predispose and induce LVNC disease.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1550: Molecular Circuits of Heart Disease
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Eileen E. M. Furlong, Ph.D.