Random monoallelic gene expression in inherited cardiomyopathies (A09)

• Subject Area: Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 464424253

Genes displaying random monoallelic expression (RME) are often associated with autosomal dominant disorders including cardiomyopathies. However, the impact of RME in heart diseases and the epigenetic mechanisms underlying RME are largely unexplored. Here, we propose to gain mechanistic understanding of how RME is regulated in the context of inherited cardiomyopathies using both genomics approaches and genetic engineering. An understanding of the epigenetic control of RME genes could enable the development of ‘epidrug’ treatments in heart pathologies.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1550: Molecular Circuits of Heart Disease
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professorin Dr. Edith Heard, Ph.D.